About this Research Topic
ICD is rapidly drawing much attention from the scientific community in the field of cancer therapy. In this Research topic, we would like to shed light on ICD going insights into the molecular mechanisms characterizing its various forms, and the potential clinical applications it may be implied with. The clinical relevance of ICD and cancer treatment is very promising. Some conventional treatments have already demonstrated their ability to induce some forms of ICD, and currently, new ICD inducers are under screening. Gaining more information on ICD mechanisms and new possible ICD inducers could be of fundamental importance in the clinic as it may lead to the identification and development of new effective anti-cancer agents.
The Research topic welcomes all types of work that have the potential to unravel novel aspects of ICD, from the mechanistic point of view to the clinical translatability. Potential contributions may address one of the following topics:
• Identification of novel ICD inducers
• Molecular mechanisms and targets of ICD
• Establishment of new methods for ICD detection
• Clinical application of ICD
• New insight on DAMPs
• Factors inhibiting DAMPs
We accept different article types including Mini-Reviews, Brief Research Reports and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.
Keywords: Immunogenic Cell Death (ICD), Damage-associated molecular patterns (DAMPs), Tumor immunophenotype, Tumor microenvironment (TME), Anti-tumor Immune responses, Tumor neoantigens, Cancer immunogenicity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.