About this Research Topic
The ribosome is one of the oldest pieces of molecular machinery, involved in maintaining the central dogma of life by ensuring the flow of genetic information from RNA to protein. Ribosome biogenesis is a complex and tightly regulated process that occurs in nucleolar organizer regions (NORs) of the nucleolus. Ribosome biogenesis is essential for cellular vitality. Increased ribosome biogenesis and related increase in nucleolar number and size are associated with aging, cancer, and several neurodegenerative disorders such as Alzheimer, Parkinson, Huntington, and other advanced age-related diseases. It is well-established that protein translation is proportional to the rate of ribosome biogenesis. Upregulation of protein synthesis and disruption of global proteostasis is the mechanism that promotes aging. Impairment ribosome biogenesis can result in cell cycle arrest by p53 dependent and independent pathway, recently termed as the impaired ribosome biogenesis checkpoint (IRBC)
Current knowledge of ribosome biogenesis is largely based on genetic studies conducted in the yeast Saccharomyces cerevisiae. However recent genetic screens identify nucleolar proteins and/or processing factors that do not have any yeast homolog. Exploration of the ribosome biogenesis process and identification of regulatory factors, or regulatory RNAs (lncRNAs, snoRNAs) can identify possible potential therapeutic targets against multiple pathological conditions.
This research topic is primarily interested in the following topics:
Recent advances or research toward exploring ribosome biogenesis and its role in pathologic conditions like neurodegeneration, cancer, and aging.
Recent discoveries exploring ribosome biogenesis, rRNA transcription, nucleolar dysregulation
Studies exploring the regulatory role of ribosomal proteins, small nucleolar RNAs, lncRNAs in rRNA transcription, nucleolar function, ribosome biogenesis
Genes and mechanisms that intercept genetic and epigenetic mutations involved in hyperactivated ribosome biogenesis
Experimental, clinical studies evaluating novel therapies targeting nucleolus/ ribosome biogenesis aiming to develop a novel therapy
Experimental studies, in vivo models, review articles, meta-analyses, and epidemiological studies are all welcome for publication
Bioinformatic studies are welcome, however, these should not be based solely on analysis of publicly available datasets such as TCGA. It is essential to have an independent validation cohort for statistically significant confirmation of the findings communicated
Current knowledge of ribosome biogenesis is largely based on genetic studies conducted in the yeast Saccharomyces cerevisiae. However recent genetic screens identify nucleolar proteins and/or processing factors that do not have any yeast homolog. Exploration of the ribosome biogenesis process and identification of regulatory factors, or regulatory RNAs (lncRNAs, snoRNAs) can identify possible potential therapeutic targets against multiple pathological conditions.
This research topic is primarily interested in the following topics:
Recent advances or research toward exploring ribosome biogenesis and its role in pathologic conditions like neurodegeneration, cancer, and aging.
Recent discoveries exploring ribosome biogenesis, rRNA transcription, nucleolar dysregulation
Studies exploring the regulatory role of ribosomal proteins, small nucleolar RNAs, lncRNAs in rRNA transcription, nucleolar function, ribosome biogenesis
Genes and mechanisms that intercept genetic and epigenetic mutations involved in hyperactivated ribosome biogenesis
Experimental, clinical studies evaluating novel therapies targeting nucleolus/ ribosome biogenesis aiming to develop a novel therapy
Experimental studies, in vivo models, review articles, meta-analyses, and epidemiological studies are all welcome for publication
Bioinformatic studies are welcome, however, these should not be based solely on analysis of publicly available datasets such as TCGA. It is essential to have an independent validation cohort for statistically significant confirmation of the findings communicated
Keywords: Ribosome Biogenesis, Impaired Ribosome Biogenesis Checkpoint (IRBC), rRNA Transcription, Novel Drug Target
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