About this Research Topic
Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb), remains one of the top killers among infectious diseases. Host cells, such as macrophages and dendritic cells, as the key immune component of innate immunity against pathogens, can phagocytose and destroy different pathogens, and initiate protective adaptive immune responses via antigen presentation to T cells. Mtb is unanimously recognized as one of the most successful human pathogens due to its strong ability to persist and survive in the host cells of immunocompetent individuals. Upon Mtb infection, the battles between Mtb and host cells are activated to initiate the innate responses for the immune system or to spread the virulence of Mtb for the deadly Mtb pathogen.
After the phagocytose of Mtb into the host cell compartments, several different fates would happen to the Mtb and host cells. For host cells, some different kinds of death fates may happen to kill the intracellular Mtb actively or suffer from the virulence of Mtb passively, which are closely associated with host cell necrosis, apoptosis, autophagy, pyroptosis, and ferroptosis. Thus, host cell death fates upon Mtb infection are closely associated with host cell immunological responses and Mtb virulence. A more depth understanding of host cell death would be helpful to know the pathogen and host cell interactions during Mtb infection and will finally benefit the development of more effective anti-TB strategies.
This Research Topic focuses on the mechanisms of host cell death-associated immunological responses for intracellular Mtb killings controlled by anti-TB immunity and host cell death-associated immune escape mechanisms for intracellular Mtb survival induced by Mtb virulence, which may introduce new insight into TB immunity. Another goal of this Research Topic is also aimed to gather together cutting-edge research or views on host cell death-associated strategies for intracellular Mtb killings, which is expected to provide new targets for the development of anti-TB immunotherapy strategies.
Original Research, Perspectives, and Reviews are welcomed. Subtopics may include but are not limited to:
• Necrosis-associated host responses/mechanisms upon Mtb infection
• Apoptosis-associated host responses/mechanisms upon Mtb infection
• Autophagy-associated host responses/mechanisms upon Mtb infection
• Pyroptosis-associated host responses/mechanisms upon Mtb infection
• Ferroptosis-associated host responses/mechanisms upon Mtb infection
• Novel host cell death mechanisms upon Mtb infection
• Anti-TB strategies targeting host cell death mechanisms
After the phagocytose of Mtb into the host cell compartments, several different fates would happen to the Mtb and host cells. For host cells, some different kinds of death fates may happen to kill the intracellular Mtb actively or suffer from the virulence of Mtb passively, which are closely associated with host cell necrosis, apoptosis, autophagy, pyroptosis, and ferroptosis. Thus, host cell death fates upon Mtb infection are closely associated with host cell immunological responses and Mtb virulence. A more depth understanding of host cell death would be helpful to know the pathogen and host cell interactions during Mtb infection and will finally benefit the development of more effective anti-TB strategies.
This Research Topic focuses on the mechanisms of host cell death-associated immunological responses for intracellular Mtb killings controlled by anti-TB immunity and host cell death-associated immune escape mechanisms for intracellular Mtb survival induced by Mtb virulence, which may introduce new insight into TB immunity. Another goal of this Research Topic is also aimed to gather together cutting-edge research or views on host cell death-associated strategies for intracellular Mtb killings, which is expected to provide new targets for the development of anti-TB immunotherapy strategies.
Original Research, Perspectives, and Reviews are welcomed. Subtopics may include but are not limited to:
• Necrosis-associated host responses/mechanisms upon Mtb infection
• Apoptosis-associated host responses/mechanisms upon Mtb infection
• Autophagy-associated host responses/mechanisms upon Mtb infection
• Pyroptosis-associated host responses/mechanisms upon Mtb infection
• Ferroptosis-associated host responses/mechanisms upon Mtb infection
• Novel host cell death mechanisms upon Mtb infection
• Anti-TB strategies targeting host cell death mechanisms
Keywords: Cell Death, Mycobacterium Tuberculosis, Novel Target, Immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
