About this Research Topic
Our aim is to thoroughly examine stem cell types that are being utilized for regeneration of cardiovascular tissues and organs, which were damaged or abnormal due to congenital defects or disease conditions. In this context, we would like to deeply investigate the role of iPSCs and MSCs in cardiac and vascular regeneration and examine the major challenges those candidate stem cell types face in clinical applications, from cell isolation, expansion, delivery, survival and engraftment, off-targeting effect, tumor formation, to mutagenesis. In cardiac tissue regeneration, we also would like to examine major concerns of arrythmias with transplantation of stem cells/ stem cells-derived cardiomyocytes and understand molecular mechanisms to mitigate those conditions. In vascular regeneration, we would like to focus on role and mechanisms of stem/progenitor cells in the growth of new blood vessels, reversal of vascular damage, and restoration of normal vascular structure and function. We
would like to examine how academia and industries are partnering and fostering their findings and what challenges they are facing in the field.
The overall goal is to gain practical insight on how close the stem cell therapy in is regenerating cardiac and vascular tissues in the bed side. We anticipate that this collection of original research articles and review papers will provide researchers and clinicians a vision on what has been done in the field and identify the gaps that need to be timely and thoroughly addressed to accelerate the scope of stem cells in cardiovascular medicine.
Keywords: cardiovascular disease, stem cell therapy, BM-MSC, iPSCs, cardiovascular medicine, regenerative medicine
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