About this Research Topic
Copper is an indispensable trace element in organisms and plays a wide and important role in biological systems. When the intracellular copper ion concentration exceeds the threshold, it will also show cytotoxicity.
Cuproptosis is an independent form of cell death that was considered to be highly correlated with mitochondrial respiration and the lipoic acid pathway. Quite a few researchers have focused on the relationship between cuproptosis and cancers. On the one hand, both cuproptosis and cancer are closely associated with cellular metabolism and immune response homeostasis. On the other hand, more and more studies have shown that the expression levels of cuproptosis key genes can be used to predict immunotherapy efficacy in cancers. In addition, copper ions played an important role in the discovery of copper death and were thought to have the potential for anti-tumor therapy in the past. However, it is unclear whether cuproptosis can affect cancer immunotherapy and its specific mechanisms.
The goal of this Research Topic is to provide a forum to explore the role of cuproptosis in cancer immunotherapy and its regulatory mechanisms. We aim to explore the potential value of cuproptosis as a biomarker of cancer immunotherapy and develop cuproptosis-related drugs to provide new methods for cancer treatment.
We welcome Original Research and Review articles. Potential subtopics include but are not limited to the following:
• Mechanisms of cuproptosis
• Cuproptosis and cancer immunity
• Cuproptosis and immune response homeostasis
• Construction of immunotherapy evaluation models based on cuproptosis key genes
• Construction of cancer prognosis models based on cuproptosis key genes
• Cuproptosis and targeted therapy in cancer
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Cuproptosis is an independent form of cell death that was considered to be highly correlated with mitochondrial respiration and the lipoic acid pathway. Quite a few researchers have focused on the relationship between cuproptosis and cancers. On the one hand, both cuproptosis and cancer are closely associated with cellular metabolism and immune response homeostasis. On the other hand, more and more studies have shown that the expression levels of cuproptosis key genes can be used to predict immunotherapy efficacy in cancers. In addition, copper ions played an important role in the discovery of copper death and were thought to have the potential for anti-tumor therapy in the past. However, it is unclear whether cuproptosis can affect cancer immunotherapy and its specific mechanisms.
The goal of this Research Topic is to provide a forum to explore the role of cuproptosis in cancer immunotherapy and its regulatory mechanisms. We aim to explore the potential value of cuproptosis as a biomarker of cancer immunotherapy and develop cuproptosis-related drugs to provide new methods for cancer treatment.
We welcome Original Research and Review articles. Potential subtopics include but are not limited to the following:
• Mechanisms of cuproptosis
• Cuproptosis and cancer immunity
• Cuproptosis and immune response homeostasis
• Construction of immunotherapy evaluation models based on cuproptosis key genes
• Construction of cancer prognosis models based on cuproptosis key genes
• Cuproptosis and targeted therapy in cancer
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Keywords: Cuproptosis, Cancer Immunotherapy, Molecular Mechanism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
