About this Research Topic
Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are characterized by their capabilities for self-renewal and pluripotency. Self-renewal refers to the cell's ability to proliferate indefinitely, while pluripotency denotes the cell's capacity to differentiate into specialized cell types from any of the three primary germ layers: ectoderm, endoderm, or mesoderm.
In basic research, PSCs serve as a potent tool for studying embryogenesis, gene function, and developmental biology. In the realm of biomedical research, they are utilized to explore the pathogenesis of human genetic diseases, cell therapy, and tissue engineering. They also aid in identifying novel diagnostic and prognostic biomarkers and in testing new drugs. The significance of
PSC research lies in its vast potential for clinical applications. The potential applications of PSCs have broadened, especially with modern advancements such as CRISPR/Cas9 genetic editing,
biomaterials, and 3D printing. PSCs, capable of differentiating into a wide array of cell subtypes and, in conjunction with tissue engineering, may be developed into tissues and organs. Therefore,
research related to these cells, coupled with an enhanced understanding of their properties, can greatly expand their use in various domains.
This collection invites submissions related to, but not limited to, the following subthemes:
• Novel protocols for the isolation of PSCs
• Utilization of small molecules in the culture of PSCs
• Signaling pathways in the maintenance of PSCs
• Differentiation processes of PSCs
• Manipulative techniques in PSC research
• Application of PSCs in tissue engineering and cell therapy
• Application of PSCs in human disease modelling.
In basic research, PSCs serve as a potent tool for studying embryogenesis, gene function, and developmental biology. In the realm of biomedical research, they are utilized to explore the pathogenesis of human genetic diseases, cell therapy, and tissue engineering. They also aid in identifying novel diagnostic and prognostic biomarkers and in testing new drugs. The significance of
PSC research lies in its vast potential for clinical applications. The potential applications of PSCs have broadened, especially with modern advancements such as CRISPR/Cas9 genetic editing,
biomaterials, and 3D printing. PSCs, capable of differentiating into a wide array of cell subtypes and, in conjunction with tissue engineering, may be developed into tissues and organs. Therefore,
research related to these cells, coupled with an enhanced understanding of their properties, can greatly expand their use in various domains.
This collection invites submissions related to, but not limited to, the following subthemes:
• Novel protocols for the isolation of PSCs
• Utilization of small molecules in the culture of PSCs
• Signaling pathways in the maintenance of PSCs
• Differentiation processes of PSCs
• Manipulative techniques in PSC research
• Application of PSCs in tissue engineering and cell therapy
• Application of PSCs in human disease modelling.
Keywords: Pluripotent stem cells, embryonic stem cells, induced pluripotent stem cells, signalling pathway, Differentiation
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