About this Research Topic
Ferroptosis is a relatively new form of regulated cell death discovered in 2012 which has seen exponential interest in recent years and differs from other forms of regulated cell death (such as Apoptosis and Necroptosis) in morphology, genetic mechanism, biochemical and immunological regulation with a link to multiple cellular metabolic pathways. Current understanding of the triggers for ferroptosis is through lipid peroxidation by an inhibition of glutathione peroxidase 4 and an excessive accumulation of intracellular iron ions.
Interestingly, it has been found that therapy resistant-cancer cells are very vulnerable to ferroptosis. As such, the pharmacological use of ferroptosis, through either inhibition or induction, holds great potential therapeutically for drug-resistant cancers as well as other degenerative diseases that have been linked to lipid peroxidation. Though our understanding of ferroptosis continues to expand, there are still several challenges that can be identified, particularly in terms of regulatory mechanisms in multiple disorders and as well as further application to clinical cancer-based therapy.
This Research Topic seeks to further our knowledge understanding in ferroptosis and unravel its mechanisms that lead to cell death. And create discussion that informs future researchers on the current challenges in this field of study. This collection therefore welcomes articles of all types (Original Research, Review, Methods, Perspectives, etc.) covering, but not limited to:
- Ferroptosis and it’s pathway triggers
- Molecular mechanisms and regulatory networks associated with ferroptosis
- Role of Iron in ferroptosis
- Physiological functions and regulation in tumor suppression, neurological disorders, kidney and liver disease
- Role in cancer therapy and use in combination with conventional therapeutic modalities
- Future challenges in terms of regulatory mechanisms
Interestingly, it has been found that therapy resistant-cancer cells are very vulnerable to ferroptosis. As such, the pharmacological use of ferroptosis, through either inhibition or induction, holds great potential therapeutically for drug-resistant cancers as well as other degenerative diseases that have been linked to lipid peroxidation. Though our understanding of ferroptosis continues to expand, there are still several challenges that can be identified, particularly in terms of regulatory mechanisms in multiple disorders and as well as further application to clinical cancer-based therapy.
This Research Topic seeks to further our knowledge understanding in ferroptosis and unravel its mechanisms that lead to cell death. And create discussion that informs future researchers on the current challenges in this field of study. This collection therefore welcomes articles of all types (Original Research, Review, Methods, Perspectives, etc.) covering, but not limited to:
- Ferroptosis and it’s pathway triggers
- Molecular mechanisms and regulatory networks associated with ferroptosis
- Role of Iron in ferroptosis
- Physiological functions and regulation in tumor suppression, neurological disorders, kidney and liver disease
- Role in cancer therapy and use in combination with conventional therapeutic modalities
- Future challenges in terms of regulatory mechanisms
Keywords: Ferroptosis, Lipid Peroxidation, GLP4, Cancer-based therapy, Tumor Suppression
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