About this Research Topic
Glycosylation, the most prevalent post-translational modification of proteins, plays a crucial role in the immune system, as nearly all immune receptors and membrane-bound proteins are glycosylated. Glycosylation is essential for the function of immune cells, with glycan-mediated interactions offering a novel mechanism for regulating plasma membrane organization and downstream signaling pathways. Recent studies have highlighted the importance of glycan binding proteins, such as siglecs or galectins, in forming membrane domains that modulate various immune processes, including pathogen recognition, migration, antigen presentation, antibody function, T cell activation, and cancer immune evasion. Despite these advances, there remains a need for further investigation into the mechanisms by which glycans and their interacting proteins impact cellular functions and their potential biomedical applications, such as in cancer and immunotherapies.
This research topic aims to gather contributions from leading experts in glycan immunology, utilizing biochemistry, immunology, microscopy, and molecular tools to explore the function of glycan-mediated interactions in determining immune cell function. The primary objectives include understanding how these interactions influence immune processes and identifying potential therapeutic applications.
To gather further insights into the immunological relevance of glycan-mediated interactions, we welcome articles addressing, but not limited to, the following themes:
- Investigation on membrane organization in immune cell function
- Proteomic analysis
- Imaging
- Antibody engineering
- Cancer immunity and immunotherapy
- Innate and adaptive immunity
- Infection and inflammation
Please Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section.
This research topic aims to gather contributions from leading experts in glycan immunology, utilizing biochemistry, immunology, microscopy, and molecular tools to explore the function of glycan-mediated interactions in determining immune cell function. The primary objectives include understanding how these interactions influence immune processes and identifying potential therapeutic applications.
To gather further insights into the immunological relevance of glycan-mediated interactions, we welcome articles addressing, but not limited to, the following themes:
- Investigation on membrane organization in immune cell function
- Proteomic analysis
- Imaging
- Antibody engineering
- Cancer immunity and immunotherapy
- Innate and adaptive immunity
- Infection and inflammation
Please Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section.
Keywords: Glycosylation, Glycan-mediated interactions, galectins
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
