About this Research Topic
With the transformation of the human disease spectrum, chronic non-infectious diseases have become the main killer of human health in modern society. The interaction between genes and the environment will cause the body’s immune function to be disordered, thereby affecting the body's homeostasis and causing various chronic non-infectious diseases. It has been revealed that the occurrence and development of most chronic diseases, such as cancer, cardiac disease, diabetes mellitus, autoimmune disease, and neuroimmune disorders, are associated with the dysregulation of the immune system.
Cell-to-cell communication is crucial to maintain homeostasis and to respond quickly to external stimuli. In addition to the direct connection between cells, this mode of communication transmits information to a large repertoire of cells that respond locally and remotely through a series of soluble factors. Extracellular vesicles (EVs) are a class of membrane structures naturally secreted by various cells with nanoscale dimensions. They carry various biological substances such as protein, RNA, DNA, etc., and transport these potential functional mediators to neighboring and distant recipient cells. There are two types of EVs, one is exosomes, and the other is microvesicles. According to their size differences, exosomes and microvesicles are also called "small" and "big" EVs.
The significant roles of EVs in regulating most chronic diseases have been well established. From the perspective of immune regulation, EVs have an innate capacity to evade recognition, transport and transfer active components to target cells. EVs could have multiple impacts on immunoregulation, including the regulation of antigen presentation and immune activation, immune suppression, and immune surveillance, thereby affecting the immune microenvironment.
This Research Topic aims to seek articles about new insights into the immunological regulation of EVs on common chronic diseases, including cancer, cardiac disease, diabetes mellitus, autoimmune disease, neuroimmune disorders, and so on. We focus on the source of EVs and the immunological regulation of existing EVs on target cells. We welcome authors to contribute with Reviews and Original Research articles covering but not limited to the following topics:
- Special molecules in EVs and their immunological functions in chronic diseases
- EVs-related genes in the regulation of chronic diseases from an immunological point of view
- Liquid biopsy of immune-related molecules in EVs for chronic diseases
- The immunological role of migrasome, a newly discovered EVs, in chronic diseases
- EVs in immunorecognition and therapeutic intervention in chronic diseases
It is worth noting that pure bioinformatics analysis of EVs-related genes in cancer without any validation is out of the current topic.
Cell-to-cell communication is crucial to maintain homeostasis and to respond quickly to external stimuli. In addition to the direct connection between cells, this mode of communication transmits information to a large repertoire of cells that respond locally and remotely through a series of soluble factors. Extracellular vesicles (EVs) are a class of membrane structures naturally secreted by various cells with nanoscale dimensions. They carry various biological substances such as protein, RNA, DNA, etc., and transport these potential functional mediators to neighboring and distant recipient cells. There are two types of EVs, one is exosomes, and the other is microvesicles. According to their size differences, exosomes and microvesicles are also called "small" and "big" EVs.
The significant roles of EVs in regulating most chronic diseases have been well established. From the perspective of immune regulation, EVs have an innate capacity to evade recognition, transport and transfer active components to target cells. EVs could have multiple impacts on immunoregulation, including the regulation of antigen presentation and immune activation, immune suppression, and immune surveillance, thereby affecting the immune microenvironment.
This Research Topic aims to seek articles about new insights into the immunological regulation of EVs on common chronic diseases, including cancer, cardiac disease, diabetes mellitus, autoimmune disease, neuroimmune disorders, and so on. We focus on the source of EVs and the immunological regulation of existing EVs on target cells. We welcome authors to contribute with Reviews and Original Research articles covering but not limited to the following topics:
- Special molecules in EVs and their immunological functions in chronic diseases
- EVs-related genes in the regulation of chronic diseases from an immunological point of view
- Liquid biopsy of immune-related molecules in EVs for chronic diseases
- The immunological role of migrasome, a newly discovered EVs, in chronic diseases
- EVs in immunorecognition and therapeutic intervention in chronic diseases
It is worth noting that pure bioinformatics analysis of EVs-related genes in cancer without any validation is out of the current topic.
Keywords: extracellular vesicles, exosome, microvesicles, chronic disease
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