About this Research Topic
In recent years, there has been a growing body of research exploring the link between patient nutrition and cancer progression, with the aim of identifying ways to improve patient outcomes through the development of new drugs and dietary interventions. These approaches recognize the different nutritional and metabolic needs of cancer cells, as well as patients under various therapy approaches may have different nutrient requirements.
Growing insight into cancer metabolism highlights the importance of nutrient supply to tumor development and therapeutic response. Cancer cells are known to modify their metabolism to meet the demands of uncontrolled cell proliferation. This includes changes in energy requirements, biosynthetic precursors, and signaling intermediates. Malignancies cells achieve this through a chain of alterations in their genetic and transcriptional and epigenomic programs. Moreover, accumulating evidence has established that diet and nutrition are the major environmental aspects and have emerged as key components in determining cancer cell metabolism. Dietary modulation would therefore need to be matched to the specific characteristics of both cancers and treatment, a precision approach requiring a detailed understanding of the mechanisms that determine the metabolic vulnerabilities of each cancer. Understanding these metabolic changes in cancer cells is important for developing effective treatment strategies, from the development of new drugs that target specific metabolic pathways to personalized nutritional plans.
In this Research Topic, we aim to promote the discussion of these emerging concepts in cancer metabolism and how diet and nutrition influence cancer cell metabolism toward new and more personalized cancer treatments. We welcome Original Research, Reviews, Mini Reviews, and Systematic Reviews that cover, but are not limited to:
- Genetic and transcriptional changes affecting patient nutrition and cancer progression
- The role of epigenomics in cancer cell nutrient availability and progression
- New drugs targeting cancer cell nutrient availability
- Patient nutrition and cancer treatments impact on cancer progression
- Nutritional screening/assessment in cancer care
- Nutritional intervention outcomes
- Supplements as adjuvant therapy in cancer
- Fasting and caloric restriction as adjuvant therapy in cancer
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Growing insight into cancer metabolism highlights the importance of nutrient supply to tumor development and therapeutic response. Cancer cells are known to modify their metabolism to meet the demands of uncontrolled cell proliferation. This includes changes in energy requirements, biosynthetic precursors, and signaling intermediates. Malignancies cells achieve this through a chain of alterations in their genetic and transcriptional and epigenomic programs. Moreover, accumulating evidence has established that diet and nutrition are the major environmental aspects and have emerged as key components in determining cancer cell metabolism. Dietary modulation would therefore need to be matched to the specific characteristics of both cancers and treatment, a precision approach requiring a detailed understanding of the mechanisms that determine the metabolic vulnerabilities of each cancer. Understanding these metabolic changes in cancer cells is important for developing effective treatment strategies, from the development of new drugs that target specific metabolic pathways to personalized nutritional plans.
In this Research Topic, we aim to promote the discussion of these emerging concepts in cancer metabolism and how diet and nutrition influence cancer cell metabolism toward new and more personalized cancer treatments. We welcome Original Research, Reviews, Mini Reviews, and Systematic Reviews that cover, but are not limited to:
- Genetic and transcriptional changes affecting patient nutrition and cancer progression
- The role of epigenomics in cancer cell nutrient availability and progression
- New drugs targeting cancer cell nutrient availability
- Patient nutrition and cancer treatments impact on cancer progression
- Nutritional screening/assessment in cancer care
- Nutritional intervention outcomes
- Supplements as adjuvant therapy in cancer
- Fasting and caloric restriction as adjuvant therapy in cancer
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: DNA modification, Transcriptional modulation, Epigenomics, Impact of nutrition on cancer, Nutritional screening, Nutritional intervention outcomes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
