Transgenic animal models create unique phenotypes in certain gene background animals, which makes them powerful and convincing tools to study human diseases, typically in mice. However, mice models don’t always generate the similar phenotypes to human diseases because of the differences in the organ structure and body size, and this wouldn't provide ideal predictions to function studies and drug tests. Large animals can become the better option, especially with current transgenic techniques that make it more efficient and feasible in large animals.

The list of novel CRISPR/Cas9-based genome editing tools is constantly expanding and providing an efficient approach to introduce a variety of precise modifications in the mammalian genome. Thus, there is a broad application in introducing human-derived mutations in strategic genes that will reproduce similar abnormalities that occur in human diseases. Therefore, with the advantages of CRISPR, small and large animal models are becoming more suitable to study and understand the molecular mechanisms that regulate the disfunction of the genes and ultimately their physiological effects. Moreover, these models establish new platforms for efficient trials of new therapeutics and more specific assessment of their molecular effects.

Our goal is to establish research improving large animal models of human disease (i.e., Sickle cell disease, Alzheimer's disease, Parkinson's disease, etc.) and genomic modification for wellness of them.

We welcome submissions of Original Research, and Review articles that cover the following aspects, but are not limited to:

• Large animal models of human diseases
• Gene editing application for biomedical and agricultural purposes
• Application of new gene editing enhancers in cells/embryos
• Animal resistance to pathogens
• New gene editing and genetic engineering applications in animal cells
• Precision editing using viral or nanoparticle delivery in animal/human cells

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Frontiers in Genome Editing

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