Ischemic cardiovascular diseases, including ischemic heart disease and ischemic stroke, constitute the leading cause of global mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance betweend myocardial blood supply and demand, whereas ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced. Previous studies have uncovered several common and distinct causes, risk factors, molecular mechanisms, and pharmacological therapies for various ischemic cardiovascular diseases. However, the fundamental cellular heterogeneity, complex cellular communication and molecular regulatory network across the dynamic continuum of ischemic cardiovascular diseases remain elusive. Therefore, further understanding of molecular basis of ischemic cardiovascular diseases is imperative to find the precise biomarkers for early diagnosis and novel strategies for poor prognosis and adverse effects.
Launching this research topic aims to bring together promising, recent, and novel trends in the field of ischemic cardiovascular research, and to lead the way in presenting novel diagnostics, interventions and treatments. We aim to highlight: (1) novel physiological and molecular mechanisms of ischemic cardiovascular diseases, (2) the causality between critical molecular events and potential early diagnosis and therapies, and (3) the application of new technologies and interdisciplinarity in ischemic cardiovascular disease research. Any novel ideas, research models, and methods in this field will be welcomed.
Areas to be covered in this research topic may include, but are not limited to:
• Cellular and molecular basis of ischemic cardiovascular diseases
• In vitro and in vivo models for ischemic cardiovascular diseases
• Novel diagnostic and therapeutic strategies
• Clinical, pathological and pathophysiological characteristics of ischemic cardiovascular diseases
Keywords:
ischemia; cardiovascular disease; therapy; cell fate transition; molecular regulator
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Ischemic cardiovascular diseases, including ischemic heart disease and ischemic stroke, constitute the leading cause of global mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance betweend myocardial blood supply and demand, whereas ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced. Previous studies have uncovered several common and distinct causes, risk factors, molecular mechanisms, and pharmacological therapies for various ischemic cardiovascular diseases. However, the fundamental cellular heterogeneity, complex cellular communication and molecular regulatory network across the dynamic continuum of ischemic cardiovascular diseases remain elusive. Therefore, further understanding of molecular basis of ischemic cardiovascular diseases is imperative to find the precise biomarkers for early diagnosis and novel strategies for poor prognosis and adverse effects.
Launching this research topic aims to bring together promising, recent, and novel trends in the field of ischemic cardiovascular research, and to lead the way in presenting novel diagnostics, interventions and treatments. We aim to highlight: (1) novel physiological and molecular mechanisms of ischemic cardiovascular diseases, (2) the causality between critical molecular events and potential early diagnosis and therapies, and (3) the application of new technologies and interdisciplinarity in ischemic cardiovascular disease research. Any novel ideas, research models, and methods in this field will be welcomed.
Areas to be covered in this research topic may include, but are not limited to:
• Cellular and molecular basis of ischemic cardiovascular diseases
• In vitro and in vivo models for ischemic cardiovascular diseases
• Novel diagnostic and therapeutic strategies
• Clinical, pathological and pathophysiological characteristics of ischemic cardiovascular diseases
Keywords:
ischemia; cardiovascular disease; therapy; cell fate transition; molecular regulator
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.