Obesity, metabolic syndrome and type 2 diabetes mellitus are reaching alarming prevalence worldwide. These three conditions are interrelated and share complex pathophysiological common soil, i.e., insulin resistance, dyslipidemia, inflammation and oxidative stress.

Lifestyle habits, such as unhealthy dietary patterns, alcohol consumption, physical inactivity, tobacco smoking are all associated with oxidative stress and inflammation and predispose to these metabolic disorders.

The earlier the mentioned disorders are recognized and treated, the greater the success of prevention and/or delay of its complications occur. Even more, the strategies on prevention of obesity even in children and adolescents, may prevent further complications in the adult period, such as cardiovascular diseases, diabetic nephropathy and retinopathy.
Systemic low-grade inflammation and oxidative stress are regarded as the main initiators of cardio-metabolic disturbances. Reactive oxygen and nitrogen species are modulators of the function of lipids, proteins and nucleic acids and when its production exceed the antioxidant defense mechanisms, a vicious circle between oxidative stress, inflammation and cardio-metabolic disturbances occurs.

The dysregulation of adipose tissue-secreted adipokines and cytokines is known to be a typical finding in the hypertrophied adipose tissue. The latter impact on insulin signaling pathways, thus leading to insulin resistance and affecting various organs besides adipose tissue, such as liver, skeletal muscles, pancreas, etc.

Although there has ben a lot of research into this issue, there is still a knowledge gap between the complex pathophysiological mechanisms that underlie obesity and obesity-related disorders. To gain better insight into the complexity of these mechanisms, much more work is required in the quest and recognition of more novel diagnostic and prognostic biomarkers for these disorders.
The aim of this Research Topic is to further explore the current trends, advancements and role of oxidative stress and inflammation in obesity, metabolic syndrome and diabetes. Original research and review articles dealing with adults, children and adolescents are welcome.

Investigations into potential topics include but are not limited to the following:

- The association between oxidative stress and cardio-metabolic disorders
- Investigation a potential novel mechanisms between oxidative stress, inflammation and obesity-related disorders
- Identification of potential novel adipokines/cytokines that are related to obesity
- Exploring therapeutic possibilities of antioxidants and different weight-loss programs in obesity-related disorders

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Frontiers in Endocrinology

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