Current transplantation techniques fall short due to several limitations. These include the use of immunosuppression and the lack of possible available donors. Although more transplants are being performed compared to previous years, the number of patients waiting for a life-saving organ continues to increase at a higher rate. This indicates that the fundamental problem in organ transplantation is still the mismatch between the demand for organs and their availability.

Moreover, long-term immunosuppression requirements after transplantation can limit the clinical use of transplants due to their adverse effects, including organ toxicity, infections, malignancies, variable graft survival, vascular problems, and lymphoproliferative conditions.

The current limitations of organ transplantation have led to the need to develop transplantable organs and tissues that can potentially be used as substitutes for donor organs.

Development of bioengineered organs offers a promising approach to increase the availability of organs for transplantation, which could offer a resolution to address these critical challenges. By bringing together various knowledge and methods from transplant immunology, tissue engineering, and stem cell biology, this pioneering technique has the potential to produce an unlimited source of donor organs for transplantation. Another advantage of creating bioengineered organs is to achieve a state where there is no need for immunosuppression, which can enhance the quality of life, minimize complications and toxicities, and eliminate the need for lifelong antirejection therapy with its associated costs. This research topic aims to investigate that how can we bioengineer new organs and tissues to circumvent the current challenges with transplantation.

We welcome original research, case reports/series, review articles, and opinion/perspective pieces on:

• Evaluation of the effectiveness, safety, and quality of the tissue-engineered product

• The different types of cells that can be used as building blocks in tissue engineering

• The external stimuli which can affect the behavior and development of cells in tissue engineering

• Ex vivo maturation of the tissue-engineered product

• Biophysical and biomechanical stimuli that can be used to influence cell behavior and tissue development in tissue engineering

• Identification of the optimal scaffold seeding methods

• Immunological considerations in bio-engineered organ transplantation

• Development of novel biomaterials for tissue engineering and their application in organ transplantation

• Innovative methods for creating vascular networks in tissue-engineered organs

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Frontiers in Transplantation

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