Not only do microbes outnumber the number of human cells in our body, they also outnumber the genetic contribution by at least 150 fold. The microbiome is thus termed the second genome. Over the last few years, the importance of the gut microbiome in human biological processes and its role in maintaining health have been understood to a great extent. Dysbiosis in the gut microbiome has led to the release of microbial components to the circulatory system. The circulating microbiome has been found to play a critical role in the clinical complications of many metabolic diseases. The identification of circulating microbial components has therefore opened up unlimited opportunities for the detection and treatment of many disorders, including obesity, diabetes, heart disease, liver disease, cancers and even neurological disorders.

The major objective of this research topic is to summarize recent findings on the role of the gut and circulating microbiome in the pathophysiology or clinical complications of diabetes. We are hopeful that understanding the alterations in the gut and circulating microbiome, and its association with diabetes, will lead to the use of circulating microbiome as a predictive tool. This research topic will be a key initiative towards translational applications of the gut and circulating microbiome in clinical practices.

Specific themes of interest include but are not limited to:
1) Taxonomical and functional diversity of the gut and circulating microbiome in diabetes among different populations
2) The role of the gut and circulating microbiome on disease etiology, pathophysiology and its response to medications and clinical procedures, in relation to diabetes
3) The relationship between the gut and circulating microbiome changes, host gene expression and disease progression
4) The impact of medications, surgical procedures, environmental exposures and physiological stress on the human microbiome and its impact on diabetes disease etiology and pathology
5) Translational perspectives of the gut and circulating microbiome in diabetes

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Frontiers in Clinical Diabetes and Healthcare

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