Epidemiology and Mechanism of multidrug-resistant Enterobacterales

Enterobacterales are among the most common causes of bacterial infections in the community and hospitalized patients. The selective pressure of antimicrobial agents used in human and veterinary medicine has resulted in a significant increase in the resistance of Enterobacterales to multiple antimicrobial agents, even some last-resort drugs, such as carbapenems, polymyxins and tigecycline. The emergence and spread of multidrug-resistant Enterobacterales poses a threat to global health, and increase the financial burden. In addition, the cross-spread of multidrug-resistant Enterobacterales among human, animal, and environmental sectors leads to the further development of resistance. The resistance mechanisms of multidrug-resistant Enterobacterales include the expression of various enzymes, the expression of efflux pumps, permeability alterations caused by porin and the mutation of the antimicrobial targets. However, the mechanisms of multidrug-resistant Enterobacterales to multiple antimicrobial agents have not been fully elucidated. Meanwhile, little is known about the resistance of multidrug-resistant Enterobacterales to novel antimicrobial agents.

This Research Topic aims to better understand the drug resistance mechanisms and epidemiology of multidrug-resistant Enterobacterales, and further analyze how resistance emerges and transmits to provide efficacious therapeutic options for multidrug-resistant Enterobacterales infections. The resistance in Enterobacterales is characterized by complex interactions involving multiple microbial populations from humans, animals, and the environment, and we encourage addressing the resistance problem by taking this complex nature into account using a coordinated approach, such as One Health.

This Research Topic welcomes submissions of Original Research or Reviews, including but not limited to the following subtopics:
• Resistance phenotype and resistance mechanisms of multidrug-resistant Enterobacterales
• Epidemiology and diversity of multidrug-resistant Enterobacterales
• In vitro or in vivo activities of novel antimicrobial agents against multidrug-resistant Enterobacterales
• Efficacious treatment options for multidrug-resistant Enterobacterales infections
• The cross-transfer of multidrug-resistant Enterobacterales among the human, animal and environment sectors

Keywords: epidemiology, resistant mechanisms, multidrug-resistant, antimicrobial agents, <i>Enterobacterales</i>

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.