About this Research Topic
Laboratory investigations remain one of the primary tools utilized in the diagnosis and monitoring of endocrine pathologies and metabolic disease. Impressive technological developments over the past few decades coupled with strides made in information technology within laboratory applications have played a significant role in improving the quality and clinical utility of laboratory testing. These technological advancements include the increased utilization and commercialization of methodologies like high-performance liquid chromatography and tandem mass spectrometry.
The combination of chromatography with tandem mass spectrometry allows for multiple analytes to be measured on a single sample with a high degree of specificity. The increased commercialization of this methodology has made it more accessible. Further engineering developments have allowed for significant progress in miniaturization of many aspects of the laboratory testing processes.
Biochemical testing in particular remains a mainstay in the work-up of individuals with suspected endocrinopathies. This together with the growing availability of molecular investigations and the burgeoning omics analyses ensures that the clinical laboratory remains central to the diagnosis and management of most endocrine disorders.
This research topic aims to highlight recent developments in clinical laboratory investigations and critically assess utility for the diagnosis and management of endocrine and metabolic related disorders. A further aim is to encourage dissemination of this information outside of the laboratory setting into the clinical community to foster increased interdisciplinary research into the utilization and role of these new tests/ methods in the assessment of patient and other health outcomes.
Specific sub-themes
- Developments in mass spectrometry for the diagnosis and monitoring of endocrinopathies and metabolic disease.
- The role of omics (genomics, proteomics, metabolomics) in the diagnosis and monitoring of endocrine related disorders and metabolic disease.
- Improvement of diagnosis of endocrine and metabolic diseases with use of point of care methods.
- Overcoming and improving current immunoassay methods.
- The 4th revolution and its influence on the diagnosis and monitoring of endocrine and metabolic disease.
- Role of advances in laboratory testing in improvement health outcomes.
We welcome submissions of original research, reviews and mini reviews
The combination of chromatography with tandem mass spectrometry allows for multiple analytes to be measured on a single sample with a high degree of specificity. The increased commercialization of this methodology has made it more accessible. Further engineering developments have allowed for significant progress in miniaturization of many aspects of the laboratory testing processes.
Biochemical testing in particular remains a mainstay in the work-up of individuals with suspected endocrinopathies. This together with the growing availability of molecular investigations and the burgeoning omics analyses ensures that the clinical laboratory remains central to the diagnosis and management of most endocrine disorders.
This research topic aims to highlight recent developments in clinical laboratory investigations and critically assess utility for the diagnosis and management of endocrine and metabolic related disorders. A further aim is to encourage dissemination of this information outside of the laboratory setting into the clinical community to foster increased interdisciplinary research into the utilization and role of these new tests/ methods in the assessment of patient and other health outcomes.
Specific sub-themes
- Developments in mass spectrometry for the diagnosis and monitoring of endocrinopathies and metabolic disease.
- The role of omics (genomics, proteomics, metabolomics) in the diagnosis and monitoring of endocrine related disorders and metabolic disease.
- Improvement of diagnosis of endocrine and metabolic diseases with use of point of care methods.
- Overcoming and improving current immunoassay methods.
- The 4th revolution and its influence on the diagnosis and monitoring of endocrine and metabolic disease.
- Role of advances in laboratory testing in improvement health outcomes.
We welcome submissions of original research, reviews and mini reviews
Keywords: Laboratory testing; tandem mass spectrometry, information technology, miniaturisation
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