About this Research Topic
Recent advances in cancer biology have led to novel insights into the disease mechanism spanning the molecular-genetics interface. However, there exists a lacuna in identifying genes and pathways that orchestrate the development and proliferation of cancers. This requires the identification of molecular mechanisms and genes modulated through epigenetic mechanisms. Ongoing research to identify drug targets and sustainable therapeutics is slowed down due to these knowledge gaps. Some cancers, like breast cancer, prostate, and colorectal cancer, have a high genetic contribution, while others initiate and progress through mechanisms not solely genetic in nature. This mandates an understanding of the integration of environmental influences with cancer-specific gene expression patterns. Identifying molecular targets, regulators, and genetic and epigenetic mechanisms that underlie cancer development is needed to achieve the global target of developing successful cancer therapeutics.
The research topic aims to highlight recent discoveries centered on the genetic and epigenetic basis of cancer initiation, proliferation, and metastasis. This will be a unique platform spanning genes and mechanisms that intercept genetic and epigenetic mutations and modulations aiming at developing cancer theranostics and precision medicine. Experimental studies, in vivo models, review articles, meta-analyses, and epidemiological studies are welcome for publication.
Bioinformatics studies are welcome. However, these should not be based solely on analysis of publicly available datasets such as TCGA. Having an independent validation cohort is essential for statistically significant confirmation of the findings communicated.
The research topic aims to highlight recent discoveries centered on the genetic and epigenetic basis of cancer initiation, proliferation, and metastasis. This will be a unique platform spanning genes and mechanisms that intercept genetic and epigenetic mutations and modulations aiming at developing cancer theranostics and precision medicine. Experimental studies, in vivo models, review articles, meta-analyses, and epidemiological studies are welcome for publication.
Bioinformatics studies are welcome. However, these should not be based solely on analysis of publicly available datasets such as TCGA. Having an independent validation cohort is essential for statistically significant confirmation of the findings communicated.
Keywords: Cancer genetics, Cancer epigenetics, Cancer causing mutations, Drug targets, Epigenetic reprogramming, Genetic mechanism of cancer development, carcinogenesis, mutation, genomic heterogeneity, therapeutic targets, invasion and metastasis, susceptibility genes, cancer microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
