Neuromuscular disorders, including myasthenia gravis and peripheral neuropathies, are a diverse group of diseases involving the dysfunctionality of the peripheral nerves and/or muscles. Clinical symptoms of neuromuscular disorder, like double vision, weakness in limbs, muscle loss, and difficulty breathing and swallowing, can happen in childhood or adulthood. Much progress has been made to understand the pathogenesis of these complex diseases.

Recently, inflammatory mechanisms have been proposed as a major contributor to the onset and progression of neuromuscular disorders. However, the underlying mechanisms are complex and their specific protective or pathogenic actions in neuromuscular disorders remain to be clarified. Understanding complex clinical phenotypes and dynamic inflammatory mechanisms of neuromuscular disorders may be helpful for identifying potential biomarkers, providing novel directions, and developing immunomodulatory therapeutics.

This Research Topic aims to provide up-to-date information on clinical phenotypes and inflammatory mechanisms in neuromuscular disorders, moving neuromuscular disorders research forward. Further understanding of immune-associated mechanisms in these disease conditions may guide the development of immunomodulatory therapeutics in the future.

We welcome the submission of manuscripts (including Original Research articles, Brief Research articles, Mini-Reviews, and Reviews) focusing on, but not limited to, the following themes:
- Neuromuscular disorders diagnosis and screening;
- Clinical phenotypes of neuromuscular disorders;
- Dynamic changes of immune cells in neuromuscular disorders;
- Systemic inflammatory events and clinical outcomes in neuromuscular disorders;
- Identification of previously underappreciated immune signatures associated with disease progression;
- Gut microbiota and immune crosstalk in neuromuscular disorders;
- Mechanistic immunological insights from animal models of neuromuscular disorders;
- Therapeutic advances and cell-based therapies for neuromuscular disorders.

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Frontiers in Immunology

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