About this Research Topic
Antimicrobial peptides (AMPs) are the most promising drug-resistance antibiotic substituents. However, to date, only a few AMPs are being used in the clinic and one of the reasons is the limited selection of currently known AMPs as potentially effective candidates for targeting pathogens. At present, most AMPs are from terrestrial animals and less than 5% are identified in marine animals. As reported, a variety of AMPs from marine animals are different from terrestrial animals due to their different living environments or habits, or even immune defense, etc. Therefore, the characterization of new AMPs from marine animals is an encouraging research hotspot.
For example, unlike terrestrial animals, the open coelom or semi-open haemal circulatory system of aquatic invertebrates results in their continuous exposure to an environment in which potential pathogens, such as bacteria, fungi, parasites, and saprophytes, may invade their bodies, and cause diseases. Therefore, their immune response is particularly effective in pathogen elimination, as evidenced by the evolutionary success of invertebrates. It is well known that invertebrates do not have an adaptive immune system and rely mainly on their innate immune system to protect them from invasion by microbial pathogens. Accordingly, marine eukaryotes, have evolved a wide variety of anti-infective molecules, ranging from AMPs, histones, fatty acids, and other structural components of cells to pigments and regulatory proteins, as strategies to protect themselves from foreign pathogenic microorganism attack.
Antimicrobial peptides (AMPs) are small molecules that exist in multicellular organisms and are important component of the innate immune system against invasion by foreign pathogens. In vivo, AMPs exert potent activity against viral, bacterial and fungal pathogens and can also modulate the immune response through multiple mechanisms. These functions are an integral part of the process of innate immunity. Otherwise, AMPs can be produced by engineering techniques or synthesized in vitro based on their gene sequences. Each recombinant or synthetic products of AMPs has its own unique activity and can be used in aquaculture, agriculture, pharmaceuticals and medicine, and the food industry.
This Research Topic encourages the submission of papers that focus on, but are not limited to, the following themes:
1. Novel or unknown AMPs identified in marine invertebrates or vertebrates, including functional and mechanism studies
2. New variants or homologous AMPs from marine invertebrates or vertebrates, including functional and mechanism studies
3. The synergistic mechanism and effects of two or more AMPs with other immune components in marine animals in vitro and in vivo
4. The synergistic mechanism and effects of AMPs with other immune components in marine animals in vitro and in vivo
5. The newly constructed or modified approaches or techniques for highly expression of individual AMPs or fusion expression in prokaryotic or eukaryotic expression systems
6. Field experiments and effect demonstration of AMP products as additives
7. Application of AMPs in aquaculture, pharmaceuticals and medicine and food industries.
For example, unlike terrestrial animals, the open coelom or semi-open haemal circulatory system of aquatic invertebrates results in their continuous exposure to an environment in which potential pathogens, such as bacteria, fungi, parasites, and saprophytes, may invade their bodies, and cause diseases. Therefore, their immune response is particularly effective in pathogen elimination, as evidenced by the evolutionary success of invertebrates. It is well known that invertebrates do not have an adaptive immune system and rely mainly on their innate immune system to protect them from invasion by microbial pathogens. Accordingly, marine eukaryotes, have evolved a wide variety of anti-infective molecules, ranging from AMPs, histones, fatty acids, and other structural components of cells to pigments and regulatory proteins, as strategies to protect themselves from foreign pathogenic microorganism attack.
Antimicrobial peptides (AMPs) are small molecules that exist in multicellular organisms and are important component of the innate immune system against invasion by foreign pathogens. In vivo, AMPs exert potent activity against viral, bacterial and fungal pathogens and can also modulate the immune response through multiple mechanisms. These functions are an integral part of the process of innate immunity. Otherwise, AMPs can be produced by engineering techniques or synthesized in vitro based on their gene sequences. Each recombinant or synthetic products of AMPs has its own unique activity and can be used in aquaculture, agriculture, pharmaceuticals and medicine, and the food industry.
This Research Topic encourages the submission of papers that focus on, but are not limited to, the following themes:
1. Novel or unknown AMPs identified in marine invertebrates or vertebrates, including functional and mechanism studies
2. New variants or homologous AMPs from marine invertebrates or vertebrates, including functional and mechanism studies
3. The synergistic mechanism and effects of two or more AMPs with other immune components in marine animals in vitro and in vivo
4. The synergistic mechanism and effects of AMPs with other immune components in marine animals in vitro and in vivo
5. The newly constructed or modified approaches or techniques for highly expression of individual AMPs or fusion expression in prokaryotic or eukaryotic expression systems
6. Field experiments and effect demonstration of AMP products as additives
7. Application of AMPs in aquaculture, pharmaceuticals and medicine and food industries.
Keywords: AMP, Antimicrobial Peptides
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
