About this Research Topic
Wound management is fundamental to the treatment of burns and trauma and is critical to the success of the therapy. Effective wound management not only reduces the time to exposure and accelerates wound healing, but also significantly reduces the risk of wound infection, improves the quality of healing, decreases the risk of scarring leading to deformity and disability, and further improves the survival rate and the quality of life of critically injured patients. Therefore, wound management has become a key concern in burns and trauma.
Currently, the main problems with wound management are that the existing repair techniques are inherently traumatic, with crude therapy that pursues speed of wound healing at the expense of quality, thereby leading the patient to medically-induced injury, strong pain and psychological stress. Specifically, the conventional skin grafting techniques have unstable survival rates and limited expansion rates, which seriously affect the speed and quality of wound healing. Existing studies have not fully revealed the molecular and cellular mechanisms of wound repair, resulting in a variety of new treatments that do not achieve the desired results. Moreover, there is a lack of efficient repair biomaterials that can both fill traumatic defects and induce local regeneration of the wounds.
In view of this, this topic seeks precise wound management strategies which means the pertinency treatment of key targets expressed at different stages of burns & trauma. For example, depending on the duration of the injury and the condition of the wound, we propose to use different types of biomaterials and operations or biomaterials loaded with different drugs to achieve better results rather than doing the fixed operations in the fixed time points.
We want to, firstly, understand more about the molecular and cellular mechanisms of wound repair. By relying on high-throughput omics bioengineering techniques and low-throughput experimental validation, we may map out the changes in pathological mechanisms of wound from injury to tissue repair, while laying the foundation (e.g. appropriate treatment time window) for the novel biotechnologies and biomaterials. Secondly, we aspire to the development of new clinical treatment techniques that will enable higher skin extension ratios, higher skin survival rates and reduced skin source attrition. Thirdly, we are also looking for novel and efficient biomaterials that can fill the wound defects and prevent wound infections, as well as induce local regeneration and accelerate wound healing.
We welcome submissions on the following topics, but are not limited to:
- The decoding of the molecular and cellular mechanisms in wound from injury to reparation by high-throughput omics bioengineering techniques and low-throughput experimental validation
- Novel clinical techniques for precise wound management
- Novel biomaterials for precise wound management
- Biomimetic and synthetic materials for constructing functional skin tissue equivalents ex vivo for precise wound management
- Biomaterials to implement regenerative medicine for in vivo replacement of functional tissues and organs for precise wound management
Currently, the main problems with wound management are that the existing repair techniques are inherently traumatic, with crude therapy that pursues speed of wound healing at the expense of quality, thereby leading the patient to medically-induced injury, strong pain and psychological stress. Specifically, the conventional skin grafting techniques have unstable survival rates and limited expansion rates, which seriously affect the speed and quality of wound healing. Existing studies have not fully revealed the molecular and cellular mechanisms of wound repair, resulting in a variety of new treatments that do not achieve the desired results. Moreover, there is a lack of efficient repair biomaterials that can both fill traumatic defects and induce local regeneration of the wounds.
In view of this, this topic seeks precise wound management strategies which means the pertinency treatment of key targets expressed at different stages of burns & trauma. For example, depending on the duration of the injury and the condition of the wound, we propose to use different types of biomaterials and operations or biomaterials loaded with different drugs to achieve better results rather than doing the fixed operations in the fixed time points.
We want to, firstly, understand more about the molecular and cellular mechanisms of wound repair. By relying on high-throughput omics bioengineering techniques and low-throughput experimental validation, we may map out the changes in pathological mechanisms of wound from injury to tissue repair, while laying the foundation (e.g. appropriate treatment time window) for the novel biotechnologies and biomaterials. Secondly, we aspire to the development of new clinical treatment techniques that will enable higher skin extension ratios, higher skin survival rates and reduced skin source attrition. Thirdly, we are also looking for novel and efficient biomaterials that can fill the wound defects and prevent wound infections, as well as induce local regeneration and accelerate wound healing.
We welcome submissions on the following topics, but are not limited to:
- The decoding of the molecular and cellular mechanisms in wound from injury to reparation by high-throughput omics bioengineering techniques and low-throughput experimental validation
- Novel clinical techniques for precise wound management
- Novel biomaterials for precise wound management
- Biomimetic and synthetic materials for constructing functional skin tissue equivalents ex vivo for precise wound management
- Biomaterials to implement regenerative medicine for in vivo replacement of functional tissues and organs for precise wound management
Keywords: wound repair, precise management, pathophysiological mechanism, novel clinical techniques, biological materials
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