About this Research Topic
With the development of critical care medicine, the clinical treatment of heatstroke patients has improved, but the mortality rate remains between 20 and 70%, and the heatstroke disability rate remains very high. According to previous studies, heatstroke and secondary multiple organ dysfunction syndromes (MODS) are caused by a complex interplay between the acute physiological changes associated with direct heat injuries, as well as the host’s inflammatory and coagulate responses. However, the underlying molecular mechanisms that cause heatstroke’s high mortality and disability rate are unknown, thus inhibiting the development of targeted and effective treatments. Further research into pathogenesis, particularly cellular and molecular pathologic mechanisms of heatstroke and heat acclimatization, is critical.
The current Research Topic will cover, but will not be limited to, the following subtopics:
1. The novel cellular and molecular mechanisms underlying heatstroke from onset to death, such as inflammation responses, immune dysfunction, endothelial injury, coagulation dysfunction, and so on;
2. The potential mechanisms of multiple organ injury during heatstroke, especially cell death, cell-cell interaction and molecular regulation;
3. Identify novel biomarkers for assessing the severity and prognosis of heatstroke;
4. Develop more accurate animal models or clinically novel predictive models or heat acclimatization models;
5. Basic and clinical research on developing new therapeutic strategies in addition to cooling treatment;
6. Heat acclimatization: Cellular, Molecular mechanisms, Enhancing techniques and methods.
Submissions are welcome for Original Research articles, Reviews, Mini-Reviews, and Perspectives.
Keywords: heatstroke, heat acclimatization, cellular and molecular mechanisms, therapy, MODS
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.