About this Research Topic
Reserve-related processes play a major role in modulating neurofunctional resources. Especially, cognitive and motor reserve refer to resources accrued over time as a result of being engaged in mentally-stimulating and motor-enhancing activities. Also, the notion of brain reserve is currently proposed as the accumulation of neural resources before the brain is affected by age-related processes. These reserve-related factors may be crucial in successful and unsuccessful ageing by preserving age-related physiological decline, exerting protection against neurodegeneration, and influencing disease progression, and rehabilitation-related changes. These factors can account for the mismatch between the severity of neuro-pathological damage and the clinical manifestations, with considerable prognostic implications.
To date, studies exploring the role of cognitive, motor, and brain reserve on the clinical evolution of age-related, and neurodegenerative phenotypes are still few. Also, fine-grain measures of reserve factors are scarce, and the underlying biological mechanisms (cellular, molecular, and neural mechanisms) are for the most part unknown. Research may help in understanding how accumulated reserve may be the outcome of specific bio-behavioral arrangements and phenotypes.
This topic calls for studies investigating the role of reserve factors acting in the life-span by preventing age-related decline, unsuccessful aging (i.e., the frailty phenotype), and slowing disease progression or enhancing rehabilitation-related changes in clinical conditions (i.e., Parkinson’s disease, Huntington’s disease, Mild Cognitive Impairment, Alzheimer’s disease, Frontotemporal dementia, and other forms of dementia, Multiple Sclerosis, etc...).
Brief Research Report, Case Report, Clinical Trial, Conceptual Analysis, Hypothesis and Theory, Methods, Mini Review, Original Research, and Systematic Review will be welcomed. Especially we are looking for:
- Cross-sectional or longitudinal studies on detecting different phenotypes characterizing high and low reserve in typical and atypical conditions, and/or the prognostic role of different levels of reserve.
- Studies proposing and/or validating new methods/measures of cognitive, motor, and brain reserve (e.g., specific neural morphometrical indexes, and pattern of functional connectivity).
- Neuroimaging studies exploring the biological substrates involved in reserve scaffolding.
To date, studies exploring the role of cognitive, motor, and brain reserve on the clinical evolution of age-related, and neurodegenerative phenotypes are still few. Also, fine-grain measures of reserve factors are scarce, and the underlying biological mechanisms (cellular, molecular, and neural mechanisms) are for the most part unknown. Research may help in understanding how accumulated reserve may be the outcome of specific bio-behavioral arrangements and phenotypes.
This topic calls for studies investigating the role of reserve factors acting in the life-span by preventing age-related decline, unsuccessful aging (i.e., the frailty phenotype), and slowing disease progression or enhancing rehabilitation-related changes in clinical conditions (i.e., Parkinson’s disease, Huntington’s disease, Mild Cognitive Impairment, Alzheimer’s disease, Frontotemporal dementia, and other forms of dementia, Multiple Sclerosis, etc...).
Brief Research Report, Case Report, Clinical Trial, Conceptual Analysis, Hypothesis and Theory, Methods, Mini Review, Original Research, and Systematic Review will be welcomed. Especially we are looking for:
- Cross-sectional or longitudinal studies on detecting different phenotypes characterizing high and low reserve in typical and atypical conditions, and/or the prognostic role of different levels of reserve.
- Studies proposing and/or validating new methods/measures of cognitive, motor, and brain reserve (e.g., specific neural morphometrical indexes, and pattern of functional connectivity).
- Neuroimaging studies exploring the biological substrates involved in reserve scaffolding.
Keywords: cognitive reserve, motor reserve, brain reserve, ageing, neurodegeneration, dementia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
