Bioinorganic chemistry is at the forefront of the understanding of all chemical aspects of life. The role trace metal ions play in biological processes is a key issue in all studies related to life sciences. The rapidly growing bioinorganic field has over the last few years become one of the fastest-growing branches of chemistry.
Traditional bioinorganic topics that have long been studied and keep evolving, include the structure/function of metalloproteins and metalloenzymes, the role essential elements play in metabolic and signaling pathways, as well as their transport, storage, and homeostasis; the fate of inorganic and coordination compounds in different biological environments whether they are metallodrugs or species that mimic and model the structure, function, and reactivity of catalytic sites.
New fields in bioinorganic chemistry continue to emerge such as the development of advanced bioinorganic materials, e.g. nanoparticles for diagnosis and therapy; and high-throughput technologies such as genomics, proteomics, and metallomics, that yield wide-ranging data sets for cellular biomolecules.
This editorial initiative, led by Professor Sylvia Draper and Professor Isabel Correia, Specialty Chief Editors of the Bioinorganic Chemistry section, and Professor Debbie Crans, Field Chief Editor of the journal, aims to showcase the latest findings in this exciting field.

This Research Topic solicits high-quality submissions that address (but are not limited to) the following:
• Synthetic chemistry: novel metal-based therapeutics, diagnostics, and biological probes
• Metal ion homeostasis and pathophysiological disorders
• Cellular processes mediated by metal species e.g. cell signaling, communication, and transport
• Systems-level analyses, such as metal metabolomics, proteomics, lipidomics, glycomics, and other omics focused on clinical research
• Neurochemistry, immunotherapy, anticancer and dual therapeutics
• New chemical tools for sensing and imaging metal species and exploring biological pathways
• New developments in the fields of Magnetic Resonance Imaging (MRI), Photodynamic Therapy (PDT), and Boron Neutron Capture (BNT);
• Natural products’ biochemistry and chemical biology for clinical use

Within each submission, authors are encouraged to identify existing and future challenges and to explain how their work seeks to address these and to advance the field.

The goal of this special edition Research Topic is to inspire, inform and provide direction and guidance to researchers in the field.

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Frontiers in Chemical Biology

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