Organelles, including endoplasmic reticulum (ER), early and late endosomes and Golgi-apparatus, are important mediators of the cellular- sorting and trafficking pathways. These organelles contribute to cell functions under normal and disturbed physiological conditions at least in part via protein modifications, anterograde and retrograde transport, recycling, and/or degradation of molecules. Organelles are key to regulating:
1. Proinflammatory responses are mediated by various cell surface receptors (such as receptors of neuropeptides, cytokines, hormones, etc.).
2. Viral entry, production and packaging, and host cytokine response upon virus infection.

Furthermore, recent advances in research provide a wealth of knowledge on how early endosomes and Golgi apparatus may serve as signaling hubs in physiological and/or pathophysiological conditions, facilitating signaling transmission in intracellular space.

In this Research topic, we aim to explore and better understand the molecular mechanisms on how ER, early and late endosomes and Golgi-apparatus regulate proinflammatory responses as signaling hubs, or serving as sites of recycling and/or degradation of molecules in the process of signal transductions mediated by cell surface receptors. In addition, we wish to improve our knowledge on the roles of the abovementioned organelles on entry, packaging and exit of various viruses. Importantly, we would like to promote communications and exchange of ideas between research scientists studying these unconventional roles of organelles across research fields . Lastly, better understanding of these molecular interactions may also promote the discovery of novel therapeutic targets.

We welcome researchers to submit reviews, perspective and/or original research in humans and in experimental models on, but not limited to the following themes:
1. Discovery of novel molecules or modifications in sequences and structures (including mutations) of known molecules that mediates intracellular trafficking and their roles in downstream signaling events of cell surface receptors and/or during viral infections
2. Identification of novel molecular interactions in organelles (including signaling transductions) that are crucial in regulating surface receptor-mediated cellular responses or specific viral infections

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Frontiers in Immunology

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