About this Research Topic
Although the pathological mechanisms of secondary damage to the brain are still not fully understood, the consequential outcomes are very similar in different forms of ABI, suggesting a unifying mechanism. It includes neuroinflammation, vascular abnormalities, broad axonal injury, focal or disseminated atrophy, neuronal circuit disruption and cognitive dysfunction. Importantly, ABI accelerates brain-aging, suggesting involvement of mechanisms such as senescence, unfolded protein response (UPR), autophagy, circadian rhythms, and a shift in metabolism. However, there are still multiple gaps in our understanding of how these processes at cellular levels bring changes at tissue levels.
This Research Topic will bring together research that addresses the changes in cellular pathways and functioning during different forms of ABI. This topic also welcomes intervention studies focused on multimodal therapies aiming to improve clinical symptoms after ABI. Understanding the connection between ABI and different cellular responses will lay a strong foundation for future research to identify signalling molecules and molecular pathways as potential drug targets for therapies leading to a healthy ageing.
This Research Topic welcomes original research articles, clinical studies, reviews, mini reviews, and perspectives towards understanding the role of the ABI in brain-aging. The current Research Topic will include, but not be limited to, the following themes:
(1) Pre-clinical research in the association between Ageing, Neuroinflammation and dementia.
(2) Pre-clinical research in cellular senescence, UPR, autophagy, circadian rhythms and, metabolism in ABI and other neurodegenerative animal models.
(3) Clinical research in cognition evaluation, neuroimaging, dementia markers, analysis of early neurodegeneration.
Keywords: Traumatic brain injury, Senescence, Aging, Dementia, Neuroinflammation Cognitive dysfunction, Alzheimer's disease, Vascular dementia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.