About this Research Topic
Panax notoginseng (Burk.) F. H. Chen is a traditional medicinal herb widely used for treating blood disorders and cardiovascular diseases for centuries. It has been included as a herbal medicine in pharmacopeias of multiple countries, and as a dietary supplement by the US Dietary Supplement Health and Education Act in 1994, which indicates its recognized therapeutic effects and safety.
Saponins are the major active components and quality markers of Panax notoginseng, exhibiting a variety of pharmacological activities of anti-coagulation, anti-inflammation, anti-oxidation, anti-tumor, and so on. Some of them have been developed to be anti-cancer adjuvants, improving efficacy and/or reducing adverse effects via synergistic activities.
Even though the therapeutic effects of Panax notoginseng have been confirmed in the clinic historically, the evidence-based pharmacological mechanisms related to Panax notoginseng as well as its saponins need to be further studied. Besides, the rationality of the current quality control method for Panax notoginseng based on the content determination of several components is sometimes questionable considering its multiple clinical efficacies and different forms. And the poor bioavailability of some saponins also impedes the further drug development of this herbal medicine.
In recent years, multiple cutting-edge molecular biological models and advanced pharmacological approaches have been applied to understanding the activities and mechanisms of Panax notoginseng as well as its components, which also allows the optimization of the quality control method for this herbal medicine. Furthermore, novel extraction solvents and methods in the pharmaceutical area have been used to obtain its saponins more effectively or develop new preparation forms with higher absorption rates, opening more opportunities for Panax notoginseng.
The Research Topic aims to present the new trends and current developments in the pharmacological research, quality control, and pharmaceutical analysis of Panax notoginseng and its saponins. The articles collected will inspire, inform, and provide direction and guidance to researchers in the field.
• Pharmacological evaluation based on molecular biological functions of Panax notoginseng or its saponins
• Novel quality control methods or techniques for Panax notoginseng
• Application of novel green solvents or methods to optimize the extraction efficiency of saponins in Panax notoginseng combined with validated bioactivities
• Application of pharmaceutical approaches to increase the bioavailability of saponins
• Elucidation of traditional medication or processing theory of Panax notoginseng based on modern chemical, pharmacological, and biomedical analyses
All manuscripts submitted to the specialty section Ethnopharmacology must follow the best-practice assessment criteria defined as the “Four Pillars of Best Practice” (see HERE) and and the ConPhyMP statement: Front. Pharmacol. 13:953205. https://doi.org/10.3389/fphar.2022.953205). Clearly a medicinal plant like P. notoginseng, which is included in various pharmacopoeias and a detailed chemical profile is needed
Saponins are the major active components and quality markers of Panax notoginseng, exhibiting a variety of pharmacological activities of anti-coagulation, anti-inflammation, anti-oxidation, anti-tumor, and so on. Some of them have been developed to be anti-cancer adjuvants, improving efficacy and/or reducing adverse effects via synergistic activities.
Even though the therapeutic effects of Panax notoginseng have been confirmed in the clinic historically, the evidence-based pharmacological mechanisms related to Panax notoginseng as well as its saponins need to be further studied. Besides, the rationality of the current quality control method for Panax notoginseng based on the content determination of several components is sometimes questionable considering its multiple clinical efficacies and different forms. And the poor bioavailability of some saponins also impedes the further drug development of this herbal medicine.
In recent years, multiple cutting-edge molecular biological models and advanced pharmacological approaches have been applied to understanding the activities and mechanisms of Panax notoginseng as well as its components, which also allows the optimization of the quality control method for this herbal medicine. Furthermore, novel extraction solvents and methods in the pharmaceutical area have been used to obtain its saponins more effectively or develop new preparation forms with higher absorption rates, opening more opportunities for Panax notoginseng.
The Research Topic aims to present the new trends and current developments in the pharmacological research, quality control, and pharmaceutical analysis of Panax notoginseng and its saponins. The articles collected will inspire, inform, and provide direction and guidance to researchers in the field.
• Pharmacological evaluation based on molecular biological functions of Panax notoginseng or its saponins
• Novel quality control methods or techniques for Panax notoginseng
• Application of novel green solvents or methods to optimize the extraction efficiency of saponins in Panax notoginseng combined with validated bioactivities
• Application of pharmaceutical approaches to increase the bioavailability of saponins
• Elucidation of traditional medication or processing theory of Panax notoginseng based on modern chemical, pharmacological, and biomedical analyses
All manuscripts submitted to the specialty section Ethnopharmacology must follow the best-practice assessment criteria defined as the “Four Pillars of Best Practice” (see HERE) and and the ConPhyMP statement: Front. Pharmacol. 13:953205. https://doi.org/10.3389/fphar.2022.953205). Clearly a medicinal plant like P. notoginseng, which is included in various pharmacopoeias and a detailed chemical profile is needed
Keywords: Panax notoginseng, saponins, quality control, network pharmacology, bioavailability, green solvents
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
