About this Research Topic
Immunomodulatory effects of accumulating Aβ and chronic inflammation are potential common denominator in both traumatic brain injury and Alzheimer’s disease. Chronic neuroinflammatory responses following brain injury may accelerate the onset and progression of neurodegenerative diseases in high-risk individuals. In addition, brain injury induced neurovascular injuries to accelerate amyloid β (Aβ) production and tau hyperphosphorylation and tau/Aβ-induced blood-brain barrier damage. However, disentangling the direct effects of brain injury from those of a slowly progressive neurodegenerative process such as cognitive impairment using clinical history and examination alone is difficult. Thus, taking a "neurodegenerative" approach to investigating chronic problems after brain injury promises to clarify diagnostic uncertainty and evaluation of novel treatments.
We invite investigators to contribute original research articles as well as review articles that will promote the neuroimaging studies (i.e., MRI, PET, EEG/MEG) in providing biomarkers of brain injury pathological development which may be of particular use in the neurodegenerative disease setting. The topics on the latest innovative methods that underline further enhancement of understanding of brain injury and neurodegenerative diseases are especially welcome. We are also interested in developing studies that more clearly link pathology and neuroimaging through multiple avenues. In addition, studies of correlations between human blood, serum, cognitive impairment and neuroimaging biomarkers can better reveal the process of neurodegenerative changes after brain injury.
Potential topics include, but are not limited to:
• Advances in revealing which brain injury can trigger neurodegeneration
• Unifying the pathogenesis of brain injury by neuroimaging techniques
• Methodological and technical research to quantify the pathogenesis of neurodegenerative disease
• Advances in revealing acting targets for treating neurodegenerative disorders
We invite investigators to contribute original research articles as well as review articles that will promote the neuroimaging studies (i.e., MRI, PET, EEG/MEG) in providing biomarkers of brain injury pathological development which may be of particular use in the neurodegenerative disease setting. The topics on the latest innovative methods that underline further enhancement of understanding of brain injury and neurodegenerative diseases are especially welcome. We are also interested in developing studies that more clearly link pathology and neuroimaging through multiple avenues. In addition, studies of correlations between human blood, serum, cognitive impairment and neuroimaging biomarkers can better reveal the process of neurodegenerative changes after brain injury.
Potential topics include, but are not limited to:
• Advances in revealing which brain injury can trigger neurodegeneration
• Unifying the pathogenesis of brain injury by neuroimaging techniques
• Methodological and technical research to quantify the pathogenesis of neurodegenerative disease
• Advances in revealing acting targets for treating neurodegenerative disorders
Keywords: Traumatic Brain injury, Neurodegenerative diseases, Stroke, Cerebral vascular disease, Neuroimaging, Neuropsychiatric, Mechanisms, Cognitive impairment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
