Many countries are witnessing an aging of the population and a rapid decline in birth rate. The global shift in population structure toward older age groups imposes great challenges to public health. The incidence of infertility and pregnancy complications is increasing with women's age. Further studies on age-related infertility and pathological pregnancy are warranted.

Female reproductive health includes the entire reproductive cycle, beginning with ovarian and endometrial function and continuing through implantation and fetal growth. Various environmental and physiological factors contribute to disturbed reproductive health, leading to infertility issues. A significant number of studies have involved functional and multiple-omics studies of reproductive tissues and organs in relation to the various reproductive health issues including endometritis, polycystic ovarian syndrome (PCOS), recurrent miscarriage, pre-eclampsia, intrauterine growth restriction (IUGR), preterm birth, and various age-associated reproductive disorders. However, the mechanisms of these disorders remain largely unknown.

The aim of the current Research Topic is to cover promising, recent, and novel research trends in the field of female reproductive health and how disruptions lead to various diseases. Areas to be covered in this Research Topic may include, but are not limited to:
• Age-related changes in the female reproductive system, such as the ovarian reserve, endometrial receptivity, and placental function;
• Immunity in female infertility states, such as PCOS, hysteromyoma, endometriosis, endometrial polyps, adenomyosis;
• Physiological interactions between embryo and endometrium;
• Multiple-omics studies of female reproductive tissues and organs in conjunction with physiological measurements on female fertility;
• Maternal immunological interactions with the fetus and related disorders;
• Pregnancy-induced changes in maternal physiological conditions e.g. placental function, maternal-fetal interface.

Manuscript types: Original Research, Brief Research Reports, Reviews and Perspectives/Opinions, but no case reports or clinical trials. All contributions to this Research Topic must be within the scope of the section and journal, as defined in the mission statements. Articles purely focusing on omics data with no physiologic measurements are not in the scope for Frontiers in Physiology.

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