Viruses, like RNA viruses, can pose an immense threat to humankind and have huge pandemic potential. Also, oncoviruses, cause 12% of cancers and account for more than 1.5 million new cases each year. Viruses harness many host cellular proteins and RNAs for their benefit. These host cellular factors are called proviral host factors and can modify or inhibit host cellular pathways. Viral effects on these pathways can be seen in flaviviruses which inhibit the mRNA degradation pathways by generating sfRNAs. Viruses like Herpes and Bunya can shut down host transcription by counteracting RNA polymerase II CTD phosphorylation. Moreover, Poliovirus has been found to destabilize the 5′–3′ RNA decay pathway proteins, including XRN1, DCP1a, DCP2, and endoribonuclease RNase L, etc. Oncogenic viruses like the Epstein-Barr virus disrupt the architecture of host cellular chromatin and repress the cellular epigenome and transcriptome. Kaposi sarcoma-associated herpesvirus (KSHV) induces widespread cytoplasmic mRNA degradation and blocks mRNA nuclear export, whereas HCV hijacks the P-body and the stress granule components. The Epstein-Barr virus protein EBNA2 and its coactivator EBNALP can control host gene expression by liquid–liquid phase separation (LLPS).
This Research Topic aims to promote research on the interactions of viruses with the host transcription and mRNA decay apparatus, focusing on, but not limited to, RNA viruses and oncogenic viruses.
For this topic, the following article types are welcome for submission: Original Research, Brief Research Report, Methods, Mini Review, and Review under the following suggested thematic areas but not limited to,
• Interplay of the virus with host transcription apparatus.
• Interplay between virus and host mRNA decay factors.
• Viral protein and cellular RNA interaction.
• Liquid–liquid phase separation (LLPS) mediated regulation of gene expression during virus infection.
Keywords:
Virus, Gene-regulation, transcription, mRNA decay, Liquid–liquid phase separation (LLPS)
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Viruses, like RNA viruses, can pose an immense threat to humankind and have huge pandemic potential. Also, oncoviruses, cause 12% of cancers and account for more than 1.5 million new cases each year. Viruses harness many host cellular proteins and RNAs for their benefit. These host cellular factors are called proviral host factors and can modify or inhibit host cellular pathways. Viral effects on these pathways can be seen in flaviviruses which inhibit the mRNA degradation pathways by generating sfRNAs. Viruses like Herpes and Bunya can shut down host transcription by counteracting RNA polymerase II CTD phosphorylation. Moreover, Poliovirus has been found to destabilize the 5′–3′ RNA decay pathway proteins, including XRN1, DCP1a, DCP2, and endoribonuclease RNase L, etc. Oncogenic viruses like the Epstein-Barr virus disrupt the architecture of host cellular chromatin and repress the cellular epigenome and transcriptome. Kaposi sarcoma-associated herpesvirus (KSHV) induces widespread cytoplasmic mRNA degradation and blocks mRNA nuclear export, whereas HCV hijacks the P-body and the stress granule components. The Epstein-Barr virus protein EBNA2 and its coactivator EBNALP can control host gene expression by liquid–liquid phase separation (LLPS).
This Research Topic aims to promote research on the interactions of viruses with the host transcription and mRNA decay apparatus, focusing on, but not limited to, RNA viruses and oncogenic viruses.
For this topic, the following article types are welcome for submission: Original Research, Brief Research Report, Methods, Mini Review, and Review under the following suggested thematic areas but not limited to,
• Interplay of the virus with host transcription apparatus.
• Interplay between virus and host mRNA decay factors.
• Viral protein and cellular RNA interaction.
• Liquid–liquid phase separation (LLPS) mediated regulation of gene expression during virus infection.
Keywords:
Virus, Gene-regulation, transcription, mRNA decay, Liquid–liquid phase separation (LLPS)
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.