Thyroid cancer is the most frequent endocrine malignant tumor, which occurs more frequently in females than in males. Its incidence has continuously increased worldwide in the last decades. The reasons for the observed increasing incidence are unclear and controversial. Several lines of evidence suggest that this increase might not be solely the consequence of more intensive and sensitive thyroid nodule diagnostic procedures with improved diagnosis of subclinical cancers.

However, potential carcinogens that may contribute to this increase in thyroid cancer occurrence remain poorly understood. Established risk factors include exposure to ionizing radiations a history or a family history of goiter. In addition, dietary factors, including iodine intake, lifestyle and obesity, endocrine disruptors and thyroid autoimmunity are relevant candidate factors. Risk factors, such as radiation and deficient iodine intake may also affect thyroid cancer prognosis by favoring more aggressive histotypes.

We welcome original as well as review articles on a broad range of topics related to the epidemiology of Thyroid Cancer of follicular cells origin, which may include clinical as well as molecular epidemiology.

Potential topics include, but are not limited to:

1. Population or cohort based as well as case control studies and other epidemiological studies focusing on genetic, epigenetic, environmental or nutritional factors associated with Thyroid Cancer occurrence and/or histotype distribution and/or aggressiveness and prognosis.
2. The role of environmental as well as therapeutical radiations in Thyroid Cancer risk and prevention.
3. The possible role of either natural or synthetic environmental endocrine disruptors, including iodine deficiency.
4. The possible role of dietetic regimens, nutraceutics or life style changes.
5. The role of thyroid autoimmunity and benign thyroid disorders.
6. The potential role of the diverse risk factors in affecting Thyroid Cancer molecular mutations and abnormalities

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Frontiers in Endocrinology

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