About this Research Topic
This Research Topic is a continuation of the article collection series, Ocular Biomechanics of Normal Aging and Disease
Biomechanical mechanisms may contribute to a large number of visual processes and pathologies, including glaucoma, keratoconus, refractive surgery, accommodation, presbyopia, myopia, hyperopia, trauma, retinal detachment, ocular development, vitreous substitution, cataract surgery, corneal transplant, and many others. Departures from homeostatic loading may drive a large number of these processes in ways we are only beginning to recognize. This Research Topic will explore how ocular biomechanics contribute to both the homeostasis and pathophysiology of the eye and visual system. It is generally unknown whether changes in load drive changes in biomechanical properties or vice versa. Clarifying driving forces for disease and elucidating the pathophysiologic response will ultimately enable the development of targeted treatments for many ocular and visual diseases for which biomechanics plays a role.
The focus of this Research Topic is identifying biomechanical factors which differentiate between homeostasis and pathogenesis. Identification of risk factors that distinguish age-related biomechanical changes from pathological biomechanical changes. Such factors may include age, genetics, oxidative stress, radiation exposure, ambient conditions, microgravity, etc. Papers will include experimental and computational biomechanical approaches which address these issues. Tissues of interest may include the cornea, sclera, vitreous humor, lamina cribrosa, lens, trabecular meshwork, zonules, ciliary body, retina, choroid, Schlemm’s canal, optic nerve, and orbital components as well as ocular membranes such as the lens capsule, Bruch’s membrane, Bowman’s membrane, Descemet’s membrane, and hyaloid membrane. Studies which seek to identify or explain complex, multifactorial pathological mechanisms are of particular interest. Similarly, studies of protective mechanisms which support, preserve, or restore homeostasis are encouraged.
Potential themes for this Topic include:
• Normal (homeostatic) aging of the eye and visual system
• Aging, genetics, and environmental causes of vision loss
• Differentiating between multiple causes of vision loss
Biomechanical mechanisms may contribute to a large number of visual processes and pathologies, including glaucoma, keratoconus, refractive surgery, accommodation, presbyopia, myopia, hyperopia, trauma, retinal detachment, ocular development, vitreous substitution, cataract surgery, corneal transplant, and many others. Departures from homeostatic loading may drive a large number of these processes in ways we are only beginning to recognize. This Research Topic will explore how ocular biomechanics contribute to both the homeostasis and pathophysiology of the eye and visual system. It is generally unknown whether changes in load drive changes in biomechanical properties or vice versa. Clarifying driving forces for disease and elucidating the pathophysiologic response will ultimately enable the development of targeted treatments for many ocular and visual diseases for which biomechanics plays a role.
The focus of this Research Topic is identifying biomechanical factors which differentiate between homeostasis and pathogenesis. Identification of risk factors that distinguish age-related biomechanical changes from pathological biomechanical changes. Such factors may include age, genetics, oxidative stress, radiation exposure, ambient conditions, microgravity, etc. Papers will include experimental and computational biomechanical approaches which address these issues. Tissues of interest may include the cornea, sclera, vitreous humor, lamina cribrosa, lens, trabecular meshwork, zonules, ciliary body, retina, choroid, Schlemm’s canal, optic nerve, and orbital components as well as ocular membranes such as the lens capsule, Bruch’s membrane, Bowman’s membrane, Descemet’s membrane, and hyaloid membrane. Studies which seek to identify or explain complex, multifactorial pathological mechanisms are of particular interest. Similarly, studies of protective mechanisms which support, preserve, or restore homeostasis are encouraged.
Potential themes for this Topic include:
• Normal (homeostatic) aging of the eye and visual system
• Aging, genetics, and environmental causes of vision loss
• Differentiating between multiple causes of vision loss
Keywords: ocular biomechanics, homeostasis, pathogenesis, pathophysiology, mechanism, computational biomechanics, experimental biomechanics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
