About this Research Topic
An exciting class of regulatory small noncoding RNAs (ncRNAs) has emerged in recent years that play key role(s) in the etiology/pathogenesis and diagnosis/prognosis of various human diseases including various hematologic and solid cancers, cardiovascular diseases including stroke/atherosclerosis, diabetes, obesity, and metabolic disorders, neuropathies, neurodegeneration including Alzheimer’s Disease, Parkinson’s Disease or Multiple Sclerosis, neurological disorders including epilepsy and muscular dystrophies, liver diseases, pulmonary fibrosis, immune-mediated inflammatory disorders and inflammatory bowel disease, gastritis, autoimmune disorders including arthritis, acromegaly, chronic kidney disease, allergic rhinitis, vitiligo, osteoporosis, obstructive sleep apnea, ocular disease, periodontitis, skeletal muscle atrophy, and parasitic diseases including leishmaniasis, amongst others. These ncRNAs include primarily microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), small interfering RNAs (siRNAs) or exosomal RNAs (exRNAs), etc. that modulate the expression of target genes thus potentially regulating protein expression in normal versus diseased individuals.
This Research Topic recognizes the importance of and seeks to explore, ncRNAs in the diagnosis, etiology, progression, prognosis, and treatment of human disease as well as novel biomarker discovery by multi-omics technologies and other methodologies. Indeed, high-throughput technologies employing deep sequencing, proteogenomic, microarrays, and quantitative real-time PCR have begun to shed new light on the architecture of ncRNA landscapes in various diseases and key signal transduction cascades modulated by these ncRNAs in disease pathology. Epigenetic control of gene expression mediated via miRNAs, for instance, has expanded our understanding of transcriptional and post-transcriptional regulation of gene expression by critical ncRNAs in the cellular milieu. Network biology approaches including the construction of relevant ncRNA networks, ncRNA-mRNA networks, and bioinformatics for mining of ncRNAs, are gaining greater relevance in the search for ‘target hubs’ or novel biomarker(s) of disease. Delineation of ncRNA signatures by transcriptomic profiling or RNA-seq, for example, is an important milestone in furthering our knowledge of the repertoire of specific ncRNAs implicated in various diseases. Further, elucidation of the specific steps of the signaling cascades where ncRNAs exert their regulatory actions will augment our understanding of diseases. This will lead to the development of (i) a novel biomarker, or biomarker signature panel, for disease; (ii) ncRNA-based companion diagnostics for diagnosis of disease; (iii) point-of-care testing devices based on ncRNAs; (iv) newer therapeutic agents that target novel biomarkers with specificity, thereby reducing toxicity; (v) ncRNA-based prophylactic approaches of the future; and, (vi) ncRNA-based prognosis of disease.
We welcome the submission of manuscripts of the following three types: (i) Short Communications; (ii) Original Research Articles; and (iii) Review Articles (Systematic Reviews, Narrative Reviews, and Scoping Reviews) including, but not limited to, the following topics:
• Elucidation of ncRNA biomarkers and/or targets in any human disease.
• Regulatory cross-talk between miRNA, lncRNA, circRNA, and mRNA in human diseases.
• Network topology of ncRNAs in human diseases.
• Role of ncRNAs in remodeling cancer stem cells and the tumor milieu.
• Signal transduction cascades impacted by ncRNAs in human diseases.
• Other applications of ncRNAs that help to push the frontiers of knowledge in human biology and translational medicine.
Note to authors: Articles acceptable for this Research Topic are limited to:
- If patient data are analyzed, a comprehensive description of the patients including sex, age, diagnostic criteria, inclusion and exclusion criteria, disease stage, therapy received, comorbidities as well as additional clinical information and assessment of drug response/effects should be included.
- If genetic, proteomics, metabolomics, or other omics data are analyzed, a comprehensive description of the methods and the rationale for the selection of the specific data studied should be provided.
- Studies related to natural compounds, herbal extracts, or traditional medicine products, will not be included in this Research Topic.
This Research Topic recognizes the importance of and seeks to explore, ncRNAs in the diagnosis, etiology, progression, prognosis, and treatment of human disease as well as novel biomarker discovery by multi-omics technologies and other methodologies. Indeed, high-throughput technologies employing deep sequencing, proteogenomic, microarrays, and quantitative real-time PCR have begun to shed new light on the architecture of ncRNA landscapes in various diseases and key signal transduction cascades modulated by these ncRNAs in disease pathology. Epigenetic control of gene expression mediated via miRNAs, for instance, has expanded our understanding of transcriptional and post-transcriptional regulation of gene expression by critical ncRNAs in the cellular milieu. Network biology approaches including the construction of relevant ncRNA networks, ncRNA-mRNA networks, and bioinformatics for mining of ncRNAs, are gaining greater relevance in the search for ‘target hubs’ or novel biomarker(s) of disease. Delineation of ncRNA signatures by transcriptomic profiling or RNA-seq, for example, is an important milestone in furthering our knowledge of the repertoire of specific ncRNAs implicated in various diseases. Further, elucidation of the specific steps of the signaling cascades where ncRNAs exert their regulatory actions will augment our understanding of diseases. This will lead to the development of (i) a novel biomarker, or biomarker signature panel, for disease; (ii) ncRNA-based companion diagnostics for diagnosis of disease; (iii) point-of-care testing devices based on ncRNAs; (iv) newer therapeutic agents that target novel biomarkers with specificity, thereby reducing toxicity; (v) ncRNA-based prophylactic approaches of the future; and, (vi) ncRNA-based prognosis of disease.
We welcome the submission of manuscripts of the following three types: (i) Short Communications; (ii) Original Research Articles; and (iii) Review Articles (Systematic Reviews, Narrative Reviews, and Scoping Reviews) including, but not limited to, the following topics:
• Elucidation of ncRNA biomarkers and/or targets in any human disease.
• Regulatory cross-talk between miRNA, lncRNA, circRNA, and mRNA in human diseases.
• Network topology of ncRNAs in human diseases.
• Role of ncRNAs in remodeling cancer stem cells and the tumor milieu.
• Signal transduction cascades impacted by ncRNAs in human diseases.
• Other applications of ncRNAs that help to push the frontiers of knowledge in human biology and translational medicine.
Note to authors: Articles acceptable for this Research Topic are limited to:
- If patient data are analyzed, a comprehensive description of the patients including sex, age, diagnostic criteria, inclusion and exclusion criteria, disease stage, therapy received, comorbidities as well as additional clinical information and assessment of drug response/effects should be included.
- If genetic, proteomics, metabolomics, or other omics data are analyzed, a comprehensive description of the methods and the rationale for the selection of the specific data studied should be provided.
- Studies related to natural compounds, herbal extracts, or traditional medicine products, will not be included in this Research Topic.
Keywords: microRNA; lncRNA; circRNA; disease; biomarker; network; sequencing; bioinformatic; target; circulating RNA; companion diagnostic; therapeutic; diagnostic; theranostic; noncoding RNA
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
