About this Research Topic
Gastrointestinal diseases are increasing in prevalence worldwide, accounting for significant health care costs. Multiple factors, including genetic, lifestyle. environmental, and pharmacological factors, have been proven to be involved in the pathogenesis of gastrointestinal diseases. Among patients suffering from gastrointestinal disorders, emerging evidence has indicated that genetic variation strongly affected the responsiveness to medications. However, many of the previous studies have not considered the potential interactions of disease traits and their influence on pharmacodynamics and pharmacokinetics in complicated disorders. Therefore, investigation in these areas has the potential to yield new insights into the pathogenesis of the gastrointestinal disease, and offer efficient drug options.
A large number of genome‐sequencing technologies and data have emerged and helped identify genetic markers associated with complex disorders and predict drug response. In particular, more researchers have paid attention to the relationships between diseases such as chronic gastrointestinal diseases and other disorders (e.g immune system diseases, nervous system diseases, and malignancies), and explored their potential comorbidities. By using genetic variants as instrumental variables, such emerging studies extremely improve our understanding of the genetic basis of complex diseases, and the development of novel pharmacological targets. These novel resources provide significant support to the field, and allow explorations into genetic variation, drug response, and the interactions between gastrointestinal diseases and other diseases.
This Research Topic aims to present the latest findings and future directions for genetic variation, drug response, and interactions between gastrointestinal diseases and their associated diseases.
Potential topics include, but are not limited to the following:
• Multi-omics approaches to identify novel pharmacological targets and their drug response, and efficacy to gastrointestinal diseases.
• Pharmacological targets for diagnosis and prognosis of gastrointestinal diseases.
• In vitro targets predictions and in vivo efficacy (drug absorption and elimination, etc.) experiments in gastrointestinal diseases.
• Novel approaches or algorithms to explore the interactions between gastrointestinal diseases and other diseases
• Novel risk factors and potential comorbidities for gastrointestinal diseases
• Genetic mechanisms, mode of action of drugs, systematic studies in the development and progression of gastrointestinal diseases
A large number of genome‐sequencing technologies and data have emerged and helped identify genetic markers associated with complex disorders and predict drug response. In particular, more researchers have paid attention to the relationships between diseases such as chronic gastrointestinal diseases and other disorders (e.g immune system diseases, nervous system diseases, and malignancies), and explored their potential comorbidities. By using genetic variants as instrumental variables, such emerging studies extremely improve our understanding of the genetic basis of complex diseases, and the development of novel pharmacological targets. These novel resources provide significant support to the field, and allow explorations into genetic variation, drug response, and the interactions between gastrointestinal diseases and other diseases.
This Research Topic aims to present the latest findings and future directions for genetic variation, drug response, and interactions between gastrointestinal diseases and their associated diseases.
Potential topics include, but are not limited to the following:
• Multi-omics approaches to identify novel pharmacological targets and their drug response, and efficacy to gastrointestinal diseases.
• Pharmacological targets for diagnosis and prognosis of gastrointestinal diseases.
• In vitro targets predictions and in vivo efficacy (drug absorption and elimination, etc.) experiments in gastrointestinal diseases.
• Novel approaches or algorithms to explore the interactions between gastrointestinal diseases and other diseases
• Novel risk factors and potential comorbidities for gastrointestinal diseases
• Genetic mechanisms, mode of action of drugs, systematic studies in the development and progression of gastrointestinal diseases
Keywords: Genetic variation, drug response, interaction, gastrointestinal diseases
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