About this Research Topic
There is great interest in finding alternatives to current animal models because they are costly, time-consuming, ethically questionable, and importantly, data from animals frequently fail to predict human responses. Recent bioengineering and stem cell culture techniques provide novel tools to simulate human clinical trials.
Organoid technology culturing normal or cancerous stem cells induces self-organizing structures, reflecting crucial features in the architecture, cell types, and functions. Micro physiological systems (MPSs) or organ-on-a-chip are another highly promising tool for cancer modeling. They contain perfusable micro channels populated by living cells and recapitulate organ-level physiology and pathophysiology by recreating tumor microenvironment (TME) in cancer development.
To realize the practical application of new cancer models in drug screening tools, the sensing systems for the new cancer model are also highly demanded as the quantitative readout. Optical, electrical, and electrochemical sensors have been developed and integrated with the new cancer models.
The goal of this research topic is to demonstrate the recent advances in cancer modeling, biosensing, and their application. Through the demonstration, the research topic will provide new insights into predicting human responses, understanding cancer biology, quantitative sensing for their activities, and how to realize the practical application for screening. The research topic will contribute to the broad community of scientists involved in cancer biology, biomedical engineering, and analytical sciences. And hopefully, the platform we are building will also bring cutting-edge ideas to a whole range of bioengineering and biotechnology, not just to cancer and tumor microenvironments.
The themes of interest are modeling and sensing systems for cancer and tumor microenvironment. However, the biological study of cancer pathology is also accepted for this theme. This Research Topic welcomes submissions related, but not limited to, the following areas:
· Tumor models
· Tumor microenvironments
· Cancer organoids
· Cancer stem cells
· Stem cell technology
· MPSs/organ-on-a-chip
· Biosensors
· Microfluidic devices
· Micro-sensors and systems for tissue engineering
Organoid technology culturing normal or cancerous stem cells induces self-organizing structures, reflecting crucial features in the architecture, cell types, and functions. Micro physiological systems (MPSs) or organ-on-a-chip are another highly promising tool for cancer modeling. They contain perfusable micro channels populated by living cells and recapitulate organ-level physiology and pathophysiology by recreating tumor microenvironment (TME) in cancer development.
To realize the practical application of new cancer models in drug screening tools, the sensing systems for the new cancer model are also highly demanded as the quantitative readout. Optical, electrical, and electrochemical sensors have been developed and integrated with the new cancer models.
The goal of this research topic is to demonstrate the recent advances in cancer modeling, biosensing, and their application. Through the demonstration, the research topic will provide new insights into predicting human responses, understanding cancer biology, quantitative sensing for their activities, and how to realize the practical application for screening. The research topic will contribute to the broad community of scientists involved in cancer biology, biomedical engineering, and analytical sciences. And hopefully, the platform we are building will also bring cutting-edge ideas to a whole range of bioengineering and biotechnology, not just to cancer and tumor microenvironments.
The themes of interest are modeling and sensing systems for cancer and tumor microenvironment. However, the biological study of cancer pathology is also accepted for this theme. This Research Topic welcomes submissions related, but not limited to, the following areas:
· Tumor models
· Tumor microenvironments
· Cancer organoids
· Cancer stem cells
· Stem cell technology
· MPSs/organ-on-a-chip
· Biosensors
· Microfluidic devices
· Micro-sensors and systems for tissue engineering
Keywords: Tumor model, Tumor microenvironment, Cancer stem cell, Micro physiological system, Organ-on-a-chip, Microfluidic devices, Biosensors, Tissue engineering
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
