About this Research Topic
Here we present the Frontiers in Gastroenterology ‘Autoimmunity in Gastroenterology’ article collection. A series dedicated to highlighting research within the field of autoimmunity, which will feature in Frontiers in Gastroenterology, Frontiers in Immunology and Frontiers in Medicine.
Almost 120 years after Donath and Landsteiner reported what is now considered to be the first demonstrated case of autoimmunity, hundreds of autoimmune phenotypes have been described – many affecting the gastrointestinal tract. While these phenotypes share common pathogenic mechanisms, as evidenced in association studies, they often manifest in a particular organ – suggesting tissue-specific mechanisms are also at play in the initial breach of immune tolerance.
The research presented here highlights the quality and diversity of researchers studying autoimmune and autoinflammatory disorders that involve the Gastrointestinal (GI) Tract. We welcome contributions in the form of original research, review, mini review, case report, hypothesis and theory, perspective, both experimental and computational studies that cover, but are not limited to, following themes:
· Autoimmune diseases of the liver (including: autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis).
· Inflammatory Bowel Diseases, Coeliac Disease.
· Autoimmune pancreatitis.
· GI tract involvement in systemic autoimmune and autoinflammatory disorders.
· Immunogenetics of autoimmune phenotypes affecting the GI tract.
· Gut microbiota and autoimmunity.
· Safety and efficacy of novel immunomodulatory therapies.
We particularly encourage submissions where the first author is a research student, a clinical resident or an early-career investigator.
Almost 120 years after Donath and Landsteiner reported what is now considered to be the first demonstrated case of autoimmunity, hundreds of autoimmune phenotypes have been described – many affecting the gastrointestinal tract. While these phenotypes share common pathogenic mechanisms, as evidenced in association studies, they often manifest in a particular organ – suggesting tissue-specific mechanisms are also at play in the initial breach of immune tolerance.
The research presented here highlights the quality and diversity of researchers studying autoimmune and autoinflammatory disorders that involve the Gastrointestinal (GI) Tract. We welcome contributions in the form of original research, review, mini review, case report, hypothesis and theory, perspective, both experimental and computational studies that cover, but are not limited to, following themes:
· Autoimmune diseases of the liver (including: autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis).
· Inflammatory Bowel Diseases, Coeliac Disease.
· Autoimmune pancreatitis.
· GI tract involvement in systemic autoimmune and autoinflammatory disorders.
· Immunogenetics of autoimmune phenotypes affecting the GI tract.
· Gut microbiota and autoimmunity.
· Safety and efficacy of novel immunomodulatory therapies.
We particularly encourage submissions where the first author is a research student, a clinical resident or an early-career investigator.
Keywords: Autoimmunity, Autoinflammatory Disorders, Autoimmune Hepatitis, Inflammatory Bowel Disease, Coeliac Disease, Gut Microbiota, Autoimmune Pancreatitis, Novel Immunomodulatory Therapies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
