About this Research Topic
Cardiovascular disease is one of the most common fatal diseases worldwide. According to the World Health Organization, the morbidity and mortality rates of cardiovascular diseases have deteriorated year by year. The lack of individualized prevention and interventions is one of the most important reasons for this.
Precision medicine was first proposed in tumor immunotherapy, where targeted therapeutic agents are selected based on the genotyping of the tumor. In recent years, precision medicine has made extremely significant breakthroughs in the field of oncology and has greatly improved the prognosis of patients with malignant tumors. Although the main pathological basis of cardiovascular diseases (including coronary atherosclerotic heart disease and heart failure) is both activation of the immune system and inflammatory responses. However, evidence in recent years suggests that in coronary heart disease and heart failure, the mechanisms of occurrence are diverse. This indicates that treatment strategies should also be diversified for patients with coronary artery disease and heart failure. Furthermore, it was also found that different treatment strategies should also be used for patients with heart failure with preserved ejection fraction and those with decreased ejection fraction. These results point out that attention should be paid to subtypes of cardiovascular disease. A targeted treatment strategy should be adopted. Even so, there is still a lack of precision medicine research in cardiovascular disease subtypes, especially the exploration of individualized cardiovascular treatment strategies based on inflammation levels and immune homeostasis.
This research topic focuses on precision medicine in cardiovascular diseases and is intended to discover new concepts in cardiovascular precision therapy. We aim to accumulate Original Research and Review articles focusing on, but not limited to:
1) New disease typing in the service of precision medicine for cardiovascular disease: genetic mutations, inflammation levels, immune cell activation status, mechanistic studies and clinical features.
2) Exploration of new therapeutic approaches based on cardiovascular disease subtypes.
3) Clinical models and non-invasive diagnostic biomarkers for predicting disease subtypes.
4) Mechanistic studies on disease subtypes.
5) Treatments for subtypes of cardiovascular diseases: in vivo and in vitro studies.
Precision medicine was first proposed in tumor immunotherapy, where targeted therapeutic agents are selected based on the genotyping of the tumor. In recent years, precision medicine has made extremely significant breakthroughs in the field of oncology and has greatly improved the prognosis of patients with malignant tumors. Although the main pathological basis of cardiovascular diseases (including coronary atherosclerotic heart disease and heart failure) is both activation of the immune system and inflammatory responses. However, evidence in recent years suggests that in coronary heart disease and heart failure, the mechanisms of occurrence are diverse. This indicates that treatment strategies should also be diversified for patients with coronary artery disease and heart failure. Furthermore, it was also found that different treatment strategies should also be used for patients with heart failure with preserved ejection fraction and those with decreased ejection fraction. These results point out that attention should be paid to subtypes of cardiovascular disease. A targeted treatment strategy should be adopted. Even so, there is still a lack of precision medicine research in cardiovascular disease subtypes, especially the exploration of individualized cardiovascular treatment strategies based on inflammation levels and immune homeostasis.
This research topic focuses on precision medicine in cardiovascular diseases and is intended to discover new concepts in cardiovascular precision therapy. We aim to accumulate Original Research and Review articles focusing on, but not limited to:
1) New disease typing in the service of precision medicine for cardiovascular disease: genetic mutations, inflammation levels, immune cell activation status, mechanistic studies and clinical features.
2) Exploration of new therapeutic approaches based on cardiovascular disease subtypes.
3) Clinical models and non-invasive diagnostic biomarkers for predicting disease subtypes.
4) Mechanistic studies on disease subtypes.
5) Treatments for subtypes of cardiovascular diseases: in vivo and in vitro studies.
Keywords: Precision medicine, cardiovascular diseases, treatment, diagnosis, subtypes
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