About this Research Topic
Estrogens influence many physiological processes in mammals, including but not limited to reproduction, cardiovascular health, bone integrity, cognition, and behavior. The steroid compound estrogen is mainly produced by the ovaries and placenta in females, and by the adrenal cortex in males. Estrogens can bind and activate estrogen receptors (ERs), thus exerting their functions. ER alpha, ER beta, and novel G-protein-coupled estrogen receptor 1 have been identified as the most prominent ERs.
It is not surprising that estrogen is also implicated in the development or progression of numerous diseases, which include but are not limited to various types of cancer, osteoporosis, neurodegenerative diseases, cardiovascular disease, insulin resistance, endometriosis, and obesity. ERs have recently been of high interest as prospective therapeutic target and different ERs targeting drugs are currently being considered for prevention and treatment of these diseases.
In this Research Topic, we welcome Original Research, Reviews, Mini-Reviews, Opinion and Perspective articles including, but not limited to, the following themes:
- Molecular mechanisms of ERs action in endocrine disorders;
- ERs as drug target for endocrine disorders;
- Endocrine tissues regulation by ERs;
- ERs molecular mechanisms in health and disease;
- Estrogen-ERs interaction and effect in health and disease.
It is not surprising that estrogen is also implicated in the development or progression of numerous diseases, which include but are not limited to various types of cancer, osteoporosis, neurodegenerative diseases, cardiovascular disease, insulin resistance, endometriosis, and obesity. ERs have recently been of high interest as prospective therapeutic target and different ERs targeting drugs are currently being considered for prevention and treatment of these diseases.
In this Research Topic, we welcome Original Research, Reviews, Mini-Reviews, Opinion and Perspective articles including, but not limited to, the following themes:
- Molecular mechanisms of ERs action in endocrine disorders;
- ERs as drug target for endocrine disorders;
- Endocrine tissues regulation by ERs;
- ERs molecular mechanisms in health and disease;
- Estrogen-ERs interaction and effect in health and disease.
Keywords: estrogen receptors, endocrine disorders, drug, therapies, target
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
