About this Research Topic
Duodenal papillary lesions of the gastrointestinal tract are uncommon. Most of them are adenomatous lesions, including adenomas, precancerous lesions adenocarcinoma and submucosal lesions such as neuroendocrine tumors of the major duodenal papilla, which are rare and can be asymptomatic. Besides the imaging examinations, the endoscopic examinations including duodenoscopy, magnifying endoscopy, chromoendoscopy, endoscopic ultrasound (EUS), endoscopic retrograde cholangiopancreatography (ERCP) and the related techniques are important for the clinical diagnosis of duodenal papillary lesions, which are critical for predicting prognosis and determining the most appropriate therapeutic approach.
The traditional surgical treatments, pancreaticoduodenectomy (the Whipple procedure) and local surgical resection (transduodenal ampullectomy) can achieve complete removal of huge ampullary lesions and invasive ampullary carcinomas. However, they are invasive and associated with relatively high mortality and morbidity rates. In addition, the role of adjuvant therapy such as chemoradiotherapy for duodenal papillary cancers is controversial. Endoscopic papillectomy (EP), an alternative to surgery, has become a safe and effective therapy to treat duodenal papillary lesions in selected patients, especially for those ampullary adenomas, intraepithelial neoplasia and early cancer in T1 stage. Several endoscopic resection techniques have been established for the lesions of the papilla, including snare polypectomy, argon plasma coagulation ablation, endoscopic mucosal resection and endoscopic submucosal dissection (ESD). Furthermore, the endoscopic palliative treatments such as ERCP-associated procedures, EUS-guided radioactive seed implantation and other EUS-guided interventional therapy, and endoscopic radiofrequency ablation therapy, etc., could also play a significant role in the management of inoperable advanced ampullary carcinomas. Nevertheless, a standardized treatment strategy for endoscopic techniques has not been established well.
The aim of this topic is to attract high-quality research focusing on the clinical diagnostic and therapeutic strategies of duodenal papillary lesions with endoscopic techniques. Authors are welcome to submit original articles and reviews related to the points below.
• Advances in the endoscopic management of ampullary lesions, such as EUS for tumor staging,
• Intensive endoscopic examinations,
• The suitable and novel endoscopic treatment strategies,
• The long-term surveillance after endoscopic treatments,
• The management of complications associated with EP
• The endoscopic therapy for inoperable ampullary cancers.
Moreover, Other articles related to the advances in the clinical diagnosis and surgical and adjuvant therapy of ampullary cancers are also welcome.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The traditional surgical treatments, pancreaticoduodenectomy (the Whipple procedure) and local surgical resection (transduodenal ampullectomy) can achieve complete removal of huge ampullary lesions and invasive ampullary carcinomas. However, they are invasive and associated with relatively high mortality and morbidity rates. In addition, the role of adjuvant therapy such as chemoradiotherapy for duodenal papillary cancers is controversial. Endoscopic papillectomy (EP), an alternative to surgery, has become a safe and effective therapy to treat duodenal papillary lesions in selected patients, especially for those ampullary adenomas, intraepithelial neoplasia and early cancer in T1 stage. Several endoscopic resection techniques have been established for the lesions of the papilla, including snare polypectomy, argon plasma coagulation ablation, endoscopic mucosal resection and endoscopic submucosal dissection (ESD). Furthermore, the endoscopic palliative treatments such as ERCP-associated procedures, EUS-guided radioactive seed implantation and other EUS-guided interventional therapy, and endoscopic radiofrequency ablation therapy, etc., could also play a significant role in the management of inoperable advanced ampullary carcinomas. Nevertheless, a standardized treatment strategy for endoscopic techniques has not been established well.
The aim of this topic is to attract high-quality research focusing on the clinical diagnostic and therapeutic strategies of duodenal papillary lesions with endoscopic techniques. Authors are welcome to submit original articles and reviews related to the points below.
• Advances in the endoscopic management of ampullary lesions, such as EUS for tumor staging,
• Intensive endoscopic examinations,
• The suitable and novel endoscopic treatment strategies,
• The long-term surveillance after endoscopic treatments,
• The management of complications associated with EP
• The endoscopic therapy for inoperable ampullary cancers.
Moreover, Other articles related to the advances in the clinical diagnosis and surgical and adjuvant therapy of ampullary cancers are also welcome.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: duodenal papillary adenomas, clinical diagnostic, therapeutic strategies, endoscopy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
