The oropharyngeal/ nasopharyngeal microbiota is increasingly being appreciated as an important mediator in the susceptibility to acute and/or chronic respiratory infections and systematic diseases due to the translocation of the oral-origin commensal or pathogens via circulation and digestive systems. The interactions between oropharyngeal/ nasopharyngeal microbiota and host mucosal immunity could offer first-line protections against potential pathogens, reversely, this dynamic community could stimulate inflammatory factors that further induce oral and gut dysbiosis, which is linked to many other illnesses.
Oropharyngeal/ nasopharyngeal microbiota urge more research attention that they deserve. The goal of this Research Topic is to provide a forum for researchers or/and practitioners to share their observations or insights to strategies, encouraging the coordination of different research fields as a foundation for clinical practice improvement.
A Research Topic on “Oropharyngeal and Nasopharyngeal Microflora: New Horizons in Human Immunity and Clinical Practice” had the bullet points as below:
1) Basic and clinical research on oropharyngeal and nasopharyngeal microbiota;
2) The correlation between oropharyngeal/ nasopharyngeal microflora and immuno-modulation;
3) The role of oropharyngeal/ nasopharyngeal microflora in early-life microbiota and immunity development, as well as pregnancy outcomes;
4) The role of oropharyngeal/ nasopharyngeal microflora in systemic diseases, such as the pathogenesis of cancer or chronic liver diseases;
5) Regulatory mechanisms of microbial-mediated immune responses interaction such as oral-lung axis, oral-gut axis, brain-oral-gut axis, oral-gut-liver axis, etc.;
6) Intervention effect of oropharyngeal and nasopharyngeal microorganisms on clinical practices;
7) Oropharyngeal and nasopharyngeal microbial markers that can be used as disease diagnosis or treatment options;
8) Systematic review for oropharyngeal and nasopharyngeal microbiome studies regarding their interaction with the host immune system or their interventional clinical practice.

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Frontiers in Immunology

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