About this Research Topic
The introduction of these first 2 commercial products ushers in a new era of cellular therapy in multiple myeloma. However, challenges to product delivery and limited durability of response remain and insight into the biology of adoptively transferred T cells and interaction with the tumor microenvironment is needed before the full potential of CAR T cell therapy can be realized in this cancer.
In this series, we aim to give a platform for the many unknowns but also challenges of CAR-T in myeloma and how groups worldwide try to understand and to tackle them. We welcome Original Research and Review articles (both basic and clinical research but also real-world descriptions, position papers or opinion pieces) describing novel CAR-T cell therapy approaches, experimental platforms to understand the biology and advance the preclinical development of CAR T cells but also discuss or tackle general challenges of this new treatment option (for the individual and society).
Potential topics include, but are not limited to:
- New CAR-T designs for enhanced efficacy and durability
- Novel basic studies to understand CAR-T cell-based anti-tumor efficacy
- Monitoring of CAR-T activity in vivo
- Mechanisms of resistance and relapse after CAR-T
- Mechanisms of early and late toxicities
- Clinical studies with relevance to CAR-T cell therapy for myeloma
- Treatment sequence (role of bridging, CAR-T in earlier lines etc.)
- Academic CAR-T (programs, challenges, manufacturing process etc.)
- Patient selection and predictors of response
- Strategies to improve accessibility (by CAR-T design itself, clinical network building, turnaround time, manufacturing etc.)
Keywords: tumor immunology, cancer immunotherapy, anti-tumor immune cells, adoptive immune cell therapy, tumor micro-environment, multiple myeloma
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.