About this Research Topic

Background

Diabetes and obesity are major health problems affecting an increasing number of individuals worldwide. Clinical studies indicate the limitations of many conventional drugs for treatment or prevention. More recently, studies highlight the effects of diet and nutrition as part of alternative and non-conventional medicine. Flavonoids are a class of phytonutrients (plant compounds) found in natural products, food supplements, or functional foods. They have wide-ranging health benefits, such as antioxidant activity, anti-inflammatory effects, immunomodulation, epigenetic regulation and modulation of cell signaling pathways, and modulation of the gut microbiota. These benefits could be valuable in treating diabetes and obesity by a) prevention (lifestyle medicine) and by b) co-application with conventional drugs that enhance their effects.

The main objective of this Research Topic is to explore the potentialities and the diversity of anti-obesity and anti-diabetes flavonoids. The role of these phytochemicals in preventing and controlling these diseases needs to be elucidated. Research published in this collection will aim to address the mechanism and the mode of action of these therapeutic or preventive biomolecules. Identifying molecular targets for these phytochemicals will pave the way for an in-depth investigation and clinical research towards the development of future drugs.

We welcome researchers and clinicians to submit original research or reviews to this Research Topic that include all aspects of this topic; examples are:

• Effect of different flavonoids in diabetes and obesity;
• Studies on the bioavailability, kinetics, or mechanism of action of flavonoids;
• Relationship between flavonoids, gut microbiota, and diabetes and obesity;
• Relationships between flavonoid intake and management of diabetes and obesity;
• Synergistic interaction of flavonoids and established therapies;
• Potential of nutraceuticals in 3P Medicine (preventive, personalized, precision);
• Human studies, especially randomized controlled trials, on the effect of flavonoids on health, mainly type 2 diabetes and obesity.

Keywords: Flavonoids, Polyphenols, Metabolic disorder diseases, Type 2 diabetes, Type 1 diabetes, Obesity

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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