About this Research Topic
Novel designs must drive technological innovations and advancements with significant functions to meet contemporary society’s challenges.
In molecular biology and cellular genetics, the central dogma exemplifies the prominent role of RNA to act as a mere messenger of the information from genomic DNA to the synthesis of various proteins. However, the RNA molecules are most versatile and are much more than mere messengers.
Several novel discoveries depicted unique mechanisms and plasticity of RNA structure and functions in the past few decades. The versatility of design and roles of various RNA forms have exponentially exploded in recent times. Increasingly, there have been a greater understanding and acceptance of noncoding RNA (miRNA, sRNA, siRNA, etc.) as a versatile and potent regulator of cellular processes in plants and other species. RNAs have enormous potential to impact our lives positively. RNAs can help regulate cellular physiology and processes via enzymatic action, diverse molecular interactions (RNA-protein, RNA-RNA, RNA-DNA, RNA-small molecules or ions), chromatin remodeling, etc.
The discovery of the abundant nature of ncRNAs in eukaryotes (plants and animals) demonstrated that plasticity empowers the coordination and regulation of gene expression, quality control, immune responses, growth, and development, which external stresses affect (biotic and abiotic pressures). Moreover, the increasing evidence of RNA plasticity in various forms and modifications in higher organisms indicates that the highly evolved regulatory mechanisms are established, which control and integrate with other complex processes like epigenetic modifications via RNA editing, splicing, and structure.
This Research Topic on “RNA Plasticity: Novel Structures, Shapes, Modifications, and Functions” will welcome full-length original research articles and review articles focused on various aspects of novel structures, modifications, and biological roles of RNA as regulatory molecules. Additionally, contributions towards short communications and perspectives will be considered.
Potential topics that are encouraged for submission to this VSI (but not limited to):
- Synthetic RNA and its applications
- Novel design and modifications of RNA
- RNAi/Silencing
- Modeling or prediction algorithms/methods: RNA stability, structure, and functions
- Novel methods or carriers for cellular delivery of RNAs or RNAi constructs
- mRNA-based vaccines/therapies
- Bench to point-of-care technologies
- Advances in guide RNA engineering for CRISPR-based techniques
- CRISPR-based approaches in RNA diagnostics
- RNA imaging, RNA labeling, and biosensing applications
- RNA Nanotechnology
Note to authors:
Presubmission inquiries are encouraged. For any query related to the current special issue, please write to: ukadam@gnu.ac.kr.
In molecular biology and cellular genetics, the central dogma exemplifies the prominent role of RNA to act as a mere messenger of the information from genomic DNA to the synthesis of various proteins. However, the RNA molecules are most versatile and are much more than mere messengers.
Several novel discoveries depicted unique mechanisms and plasticity of RNA structure and functions in the past few decades. The versatility of design and roles of various RNA forms have exponentially exploded in recent times. Increasingly, there have been a greater understanding and acceptance of noncoding RNA (miRNA, sRNA, siRNA, etc.) as a versatile and potent regulator of cellular processes in plants and other species. RNAs have enormous potential to impact our lives positively. RNAs can help regulate cellular physiology and processes via enzymatic action, diverse molecular interactions (RNA-protein, RNA-RNA, RNA-DNA, RNA-small molecules or ions), chromatin remodeling, etc.
The discovery of the abundant nature of ncRNAs in eukaryotes (plants and animals) demonstrated that plasticity empowers the coordination and regulation of gene expression, quality control, immune responses, growth, and development, which external stresses affect (biotic and abiotic pressures). Moreover, the increasing evidence of RNA plasticity in various forms and modifications in higher organisms indicates that the highly evolved regulatory mechanisms are established, which control and integrate with other complex processes like epigenetic modifications via RNA editing, splicing, and structure.
This Research Topic on “RNA Plasticity: Novel Structures, Shapes, Modifications, and Functions” will welcome full-length original research articles and review articles focused on various aspects of novel structures, modifications, and biological roles of RNA as regulatory molecules. Additionally, contributions towards short communications and perspectives will be considered.
Potential topics that are encouraged for submission to this VSI (but not limited to):
- Synthetic RNA and its applications
- Novel design and modifications of RNA
- RNAi/Silencing
- Modeling or prediction algorithms/methods: RNA stability, structure, and functions
- Novel methods or carriers for cellular delivery of RNAs or RNAi constructs
- mRNA-based vaccines/therapies
- Bench to point-of-care technologies
- Advances in guide RNA engineering for CRISPR-based techniques
- CRISPR-based approaches in RNA diagnostics
- RNA imaging, RNA labeling, and biosensing applications
- RNA Nanotechnology
Note to authors:
Presubmission inquiries are encouraged. For any query related to the current special issue, please write to: ukadam@gnu.ac.kr.
Keywords: RNA, molecular biology, plant genetics, cellular genetics, DNA, RNA structure, miRNA, sRNA, siRNA, plant cell biology, physiology, biotic, abiotic
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
