Responsive biomaterials undergo triggered changes when accompany by specific environmental inducement. These dynamic systems can leverage endogenous stimulators found locally within the body as well as exogenous inducement spatiotemporal control, providing potential clinical applications for controlled release and cancer theranostics as well as personalized medicine. The micro-environment of the diseased region is significantly different from the normal site, such as higher temperature, lower pH, or secretion of certain specific enzymes. Up to date, enormous stimuli-responsive biomaterials have been engineered with biomedical applications. These Stimuli could be chemicals such as pH, glucose, enzymes, NO, among others, or physical such as ultrasound, light, magnetic field, temperature, radiation, among others, or their combinations. For instance, the pH-responsive nanocarriers become excellent drug delivery platforms for controlled release inside the tumor site and endosomes because of the lower pH values in tumors relative to normal tissues and cells.

In this research topic, we will fundamentally focus on the novel design and synthesis of responsive biomaterials for controlled release and cancer theranostics by chemical, material, nanotechnology, and biological approaches, which could promote the development of intelligent controlled release and cancer theranostics toward clinical applications. These sciences include the organic and inorganic biomaterials synthesis and characterization, drug delivery systems design, immunology and biocompatibility at the nanoscale, and clinical practices for cancer theranostics. The research topic is relevant to areas such as pharmaceutics, cancer therapy and diagnosis, nanodevices, biosensors, gene, and drug delivery, regenerative tissue engineering, translational medicine, and cancer nanotechnology. The research topic will show excellent design methodologies and the specific clinical applications of responsive biomaterials. It will play an important role in the development of biomedical, bioengineering, and biotechnology.

The main scope of the current Research Topic focuses on innovative responsive biomaterials for controlled release and cancer theranostics. Types of manuscripts to be featured include Original Research Articles, Reviews, Mini-Reviews, Methods, Protocols, and Perspective articles. Potential topics include but are not limited to the following:

• Novel responsive biomaterials design and synthesis
• Responsive biomaterials for drug delivery system and controlled release
• Responsive biomaterials for cancer therapy and translational medicine
• Responsive biomaterials exploiting the tumor microenvironment for cancer therapy
• Responsive biomaterials for tumor imaging
• Responsive biomaterials for cancer theranostics
• Peptide-based responsive biomaterials
• Copolymer-based responsive biomaterials
• Mesoporous silica nanoparticles-based responsive biomaterials
• Two-dimensional nanomaterials-based responsive biomaterials
• Exosomes or cell-derived nanovesicles-based responsive biomaterials
• Hydrogel-based responsive biomaterials
• Microneedle-based responsive biomaterials

Submit your idea

Impact

Frontiers in Bioengineering and Biotechnology

Participating Journals

Impact