Biomaterials and implantable/interventional medical devices play an irreplaceable role in saving human life and promoting human health. Their surface properties and functions largely determine their clinic performances after the implantation. The introduction of the bioactive factors on the surfaces to design the surface biological function and construct the surface microenvironment, so as to further endow the surfaces with the ability to in-situ regulate the physiological microenvironment responses, can effectively promote wound healing and tissue repair and regeneration after the implantation. In particular, by constructing the smart bioactive surfaces on the implant surfaces that can not only mimics the in vivo three-dimensional microenvironment but also promote and induce wound healing and tissue repair through the in vivo physiological environment after the implantation, the implant can be endowed with the multi-functional ability to actively adapt to and regulate the interfacial physiological responses, so as to better promote wound healing and tissue repair and regeneration.

The current Research Topic mainly focuses on the most recent advances in smart bioactive surfaces for wounding healing and tissue repair, which can be potentially used in the clinic biomaterials and implants. Typically, the methods for fabricating the smart bioactive surfaces, the three-dimension smart hydrogel coating, the newly synthesized bioactive molecules for the smart bioactive surfaces, stimuli-responsive surfaces for wounding healing and tissue repair, etc, which can offer innovative insights and perspectives for the development of this interdisciplinary area, will be emphasized.

Areas to be covered in this Research Topic may include, but are not limited to:

• Stimuli-responsive bioactive surfaces on biomaterials or medical devices
• Tunable smart hydrogel coatings for wounding healing and tissue repair
• Surface biofunctionalization of biomaterials and implants
• The interactions between the smart bioactive surfaces and host
• The modulation mechanism of smart bioactive surfaces on interface biological responses
• Drug and gene delivery surfaces for the implants
• Immuno-modulatory bioactive surfaces
• Photodynamic and photothermal bioactive surfaces for wounding healing and tissue repair

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Frontiers in Bioengineering and Biotechnology

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