About this Research Topic
Nanomaterials can trigger or suppress the immune response thanks to the direct interaction with innate immune cells such as neutrophils, macrophages or dendritic cells and eventually adaptive immune cells, such as lymphocytes. It is crucial to investigate the pathological tissue responses induced by some nanomaterials as weel as all the potential benefits that functional materials at the nanoscale can provoke. Safe-by-design nanomaterials with “smart” surfaces or specifically-released cargoes, can be employed to mediate the immune response to prompt health recovery. Nowadays, several nanomaterials are mainly used as therapeutic agents and nanocarriers of bioactive components.
This special issue aims at discussing all the beneficial and harmful immunological aspects related to the presence of nanomaterials in the differently synthesized forms like nanoparticles, nanogels, nanofibers, nanotubes, amongst others, which can be used as nanocarriers for drug delivery systems or as substrates for tissue engineering, or implantable biosensors.
The increasing use of nanomaterials in consumer products raises concerns of potential adverse effects in humans and the environment. Nanomaterial-induced inflammation, hypersensitivity, and immunosuppression represent a key point of this collection. Articles regarding nanomaterials’ designed coating as well as the acquired corona with proteins, lipids and other macromolecules or complement opsonization are welcome. Nanomaterials with beneficial effects on immune responses may represent potential future therapeutics and will be certainly worth to be published. Authors can submit the specific themes but not limited to:
-Biocompatibility testing
-Toxicity studies
-Animal studies and histopathological studies
-Gene and protein expression with nanomaterials
-Cellular responses to nanomaterials
-Therapeutic effect of nanomaterials
Accepted manuscripts types include: Original Research, Mini Review, Opinion, Perspective, Review, and Systematic Review.
This special issue aims at discussing all the beneficial and harmful immunological aspects related to the presence of nanomaterials in the differently synthesized forms like nanoparticles, nanogels, nanofibers, nanotubes, amongst others, which can be used as nanocarriers for drug delivery systems or as substrates for tissue engineering, or implantable biosensors.
The increasing use of nanomaterials in consumer products raises concerns of potential adverse effects in humans and the environment. Nanomaterial-induced inflammation, hypersensitivity, and immunosuppression represent a key point of this collection. Articles regarding nanomaterials’ designed coating as well as the acquired corona with proteins, lipids and other macromolecules or complement opsonization are welcome. Nanomaterials with beneficial effects on immune responses may represent potential future therapeutics and will be certainly worth to be published. Authors can submit the specific themes but not limited to:
-Biocompatibility testing
-Toxicity studies
-Animal studies and histopathological studies
-Gene and protein expression with nanomaterials
-Cellular responses to nanomaterials
-Therapeutic effect of nanomaterials
Accepted manuscripts types include: Original Research, Mini Review, Opinion, Perspective, Review, and Systematic Review.
Keywords: Nanomaterials, Immunology, Tissue response, Biomaterials, Drug delivery systems, Tissue engineering
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
