About this Research Topic
Cancer is a complex multifactorial disease that to date remains one of the leading causes of death worldwide. Advances in medicine and technology can help in this battle against cancer by providing us with the necessary clinical and molecular data for a patient-centered precision care model. However, the complexity pertaining to the establishment and progression of the disease highlights the need to detect the dynamic molecular changes in the patient in real-time to successfully apply the concept of personalized precision medicine in cancer. This unmet medical need can be addressed by the identification and use of circulating biomarkers, that can be noninvasively detected in liquid biopsy samples and used for the diagnosis, monitoring, prognosis and response to therapy in cancer patients.
The goal of this Research topic is to provide a space for novel, innovative and promising studies covering different aspects of personalized precision medicine in cancer with a special focus on circulating biomarkers. Despite great efforts made in the discovery of new and accurate circulating biomarkers, one of the biggest challenges to date is the translation of research to the clinic. This is due to the non-standardized protocols used in each study along with the breadth of characteristics of each cohort and the difficulty in performing an independent validation. We will attempt to bridge this gap between research and the clinic by establishing standardized workflows and pipelines that will help translate basic research results back to the clinic, and in the context of cancer, provide optimal care for patients.
The present Research Topic will cover original research articles and selected reviews featuring circulating biomarkers in cancer and how they can be used to provide a personalized precision medicine management for patients.
The following themes will be included among the Research Topic contributions:
• Imaging and molecular approaches for detecting diagnostic, monitoring, prognostic and response to treatment circulating biomarkers in cancer patients
• Circulating biomarkers from different biological fluids
• Workflows for the standardized identification of circulating biomarkers
• Application of circulating biomarkers in the clinical setting
The Research Topic will demonstrate how current research can be exploited and apply cutting-edge research results to the bedside, offering cancer patients the most appropriate assistance care plan.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
The goal of this Research topic is to provide a space for novel, innovative and promising studies covering different aspects of personalized precision medicine in cancer with a special focus on circulating biomarkers. Despite great efforts made in the discovery of new and accurate circulating biomarkers, one of the biggest challenges to date is the translation of research to the clinic. This is due to the non-standardized protocols used in each study along with the breadth of characteristics of each cohort and the difficulty in performing an independent validation. We will attempt to bridge this gap between research and the clinic by establishing standardized workflows and pipelines that will help translate basic research results back to the clinic, and in the context of cancer, provide optimal care for patients.
The present Research Topic will cover original research articles and selected reviews featuring circulating biomarkers in cancer and how they can be used to provide a personalized precision medicine management for patients.
The following themes will be included among the Research Topic contributions:
• Imaging and molecular approaches for detecting diagnostic, monitoring, prognostic and response to treatment circulating biomarkers in cancer patients
• Circulating biomarkers from different biological fluids
• Workflows for the standardized identification of circulating biomarkers
• Application of circulating biomarkers in the clinical setting
The Research Topic will demonstrate how current research can be exploited and apply cutting-edge research results to the bedside, offering cancer patients the most appropriate assistance care plan.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Keywords: personalized precision medicine, Liquid biopsy, Cancer, Circulating biomarkers, Genetic modifications, Epigenetic modifications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
