There are several major chronic diseases caused by inflammation, including autoimmune diseases, metabolic diseases, malignant tumors, and others. Ferroptosis is a non-apoptotic cell death characterized by iron overload and lipid peroxidation. The role of inflammation in tissue homeostasis is crucial, and it can induce an imbalance in tissue homeostasis when the tissue environment changes, resulting in tissue damage. Recently, more and more studies have shown that ferroptosis plays an important role in the development of various inflammation-related diseases. Ferroptosis is involved in the progression of inflammation, such as acute lung injury, acute kidney injury, rheumatoid arthritis, inflammatory bowel disease, and neurodegenerative diseases. Iron-dependent oxidative stress and lipid peroxidation are the common characteristics of ferroptosis and inflammation-related diseases. Several antioxidants acting as iron death inhibitors have been shown to have anti-inflammatory effects in experimental models of certain diseases. Therefore, exploring the role and regulation mechanism of ferroptosis in inflammation-related diseases, screening new biomarkers, as well as developing inhibitors for ferroptosis will help us to open up more ideas and directions in the treatment of inflammation-related diseases and provide more choices for the protection of human health.

Numerous studies have shown a potential link between ferroptosis and infection and inflammation. Immune cells are important players in the above process, and macrophages are one of the types of immune cells that act as host defense by mediating inflammation and regulating iron, lipid, and amino acid metabolism. Ferroptosis causes dead cells to release damage-associated molecular patterns and lipid peroxidation that further mediate inflammatory responses. Ferroptosis inhibitors protect against inflammation-related disease organ dysfunction and inflammation. This Research Topic focuses on elucidating the relationship between inflammation-related diseases and ferroptosis. How do ferroptosis-related pathways affect inflammation; What role do inflammatory factors and mediators play in ferroptosis; Does a ferroptosis inhibitor have an anti-inflammatory effect. We look forward to screening inflammation-related disease biomarkers based on ferroptosis and finding new targeted drugs for inflammation-related diseases. We welcome studies related to pharmacological activity and also encourage computational and experimental explorations.

In this research topic, we welcome researchers to submit perspectives, original articles, reviews, comments, and letters on the topic. Including but not limited to the following topics:

• Ferroptosis in inflammatory bowel disease

• Ferroptosis in acute lung injury

• Ferroptosis in acute kidney injury

• Ferroptosis in sepsis

• Ferroptosis in infectious disease

• Ferroptosis in liver disease

• Ferroptosis in rheumatic disease

• Ferroptosis in cardiovascular disease

• Ferroptosis and inflammatory pathways

• Ferroptosis in neurodegenerative diseases

• Lipid metabolism and mediators of inflammation

• Anti-inflammatory and ferroptosis inhibitors

• Ferroptosis and immune cells

• Ferroptosis-related genes and inflammation

• Immunomodulation and ferroptosis

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Frontiers in Pharmacology

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