Role of gC1qR/p32/HABP1 in Anti-tumoral Immunity and Immune Response Against Pathogens

  • 5,701

    Total downloads

  • 15k

    Total views and downloads

About this Research Topic

Submission closed

Background

Although gC1qR was first identified as a receptor for C1q in 1992, a large body of structural and functional information accumulated to date has shown that it is a multifunctional receptor that can activate or inhibit several signaling pathways. It has a ubiquitous cellular distribution with mitochondrial, cytoplasmic and cell surface localization, as well as secreted forms. It binds to several proteins present in plasma, on the cell surface, intracellular or proteins encoded by pathogens. Thus, gC1qR plays a critical role in immunity against microbes such as HIV, HCV, Staphylococcus aureus, Porphyromonas gingivalis and also tumors. For example, the 3S motif of HIV gp41 protein, binds to gC1qR to increase PLA2G1B-driven inhibition of CD4 T-cell function in HIV-infected patients. This 3S motif is highly conserved across species and is shared by several pathogenic microorganisms, including those that are known to be associated with the development of cancer, along with various other types of disease.

gC1qR, also known as: p33, p32, and hyaluronic acid binding protein (HABP1), is encoded by the C1QBP gene, and modulates a plethora of immunological processes including those involved in infection, inflammation, autoimmunity and cancer. Due to its critical role in these diseases, gC1qR has become a suitable candidate for the development of therapeutic modalities against infection and cancer. The multifunctional role of gC1qR in the regulation of immune responses in turn, is due to its ability to bind to multiple endogenous or exogenous components. Amongst the endogenous components that bind gC1qR and regulate immune responses are C1q, the surface co-receptor DC-SIGN (CD209), and the mitochondrial antiviral signaling (MAVS) protein. In addition, gC1qR serves as a pathogen recognition receptor by virtue of its ability to bind to numerous pathogen-associated molecules, including bacterial, parasitic and viral ligands. These ligands have been shown to be involved in various infections, as well as oncogenesis. The aim of this Research Topic is therefore to reveal the advances that have been made in our efforts to understand the role of gC1qR in these diseases and provide a rationale as to why gC1qR is a suitable target for the development of therapeutic options against infection and cancer.

This Research Topic aims to provide current information to immunologists, microbiologists, oncologists and clinicians, about the role of gC1qR in immunity against pathogens and tumors.
We welcome Mini Review, Perspectives, Systematic Review (including meta-analyses) and Original Research (basic research, pre-clinical, translational, and clinical research) articles related to, but not limited to, the following topics:

- Characterization of the mode of action of gC1qR in the regulation of immune responses against pathogens or tumors
- Identification of the binding motif of endogenous or exogenous components to gC1qR involved in the regulation of immune responses
- The effect of ligand binding to gC1qR on downstream signaling (gene expression, protein expression or metabolism) in immune cells
- Omics studies that focus on the role of gC1qR in immunity against pathogens or tumors at transcriptomic, proteomic or metabolomic levels in immune cells
- Investigation of the potential of therapeutic candidates targeting gC1qR to treat infections or tumors

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Keywords: gC1qR, Tumour, Anti-Tumour, Immune Response

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Impact

  • 15kTopic views
  • 9,488Article views
  • 5,701Article downloads
View impact