About this Research Topic
Cytokine storm is an umbrella term that includes several immune disorders characterized by constitutional symptoms, systemic inflammation, and multiple organ dysfunction that, if not treated properly, can lead to multiple organ failure. Severe Acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a case in point. Patients with severe disease have been reported to have increased plasma concentrations of proinflammatory cytokines, including interleukin (IL)-6, IL-7, granulocyte-colony stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein (MIP) 1α, and tumor necrosis factor (TNF)-α. In many cases, the cytokine storm becomes the last straw that breaks the camel’s back. Therefore, Mitigating the cytokine storm is essential for maintaining immune homeostasis.
Since little is known about the effects of diets, nutrients, and bioactive substances on the occurrence and development of cytokine storms, this research topic aims to disclose novel bioactive ingredients, gut microbiota shaped by diets, and nutrients that can regulate the occurrence and severity of cytokine storm. Furthermore, it is expected to use interdisciplinary methods to study the mechanisms of these activities.
We welcome narrative and systematic reviews (including meta-analyses) and original research studies (animal model, cell model, pre-clinical, translational, and clinical research). Related themes include the following topics but not limited to:
• Research on effects of dietary patterns on inflammatory response and the homeostasis of the immune system.
• Study on anti-inflammatory and immunomodulatory mechanisms of bioactive substances in food.
• Foods, nutrients, bioactive substances, and dietary patterns affect the inflammatory response through intestinal microbiota and their metabolites.
• Study on the regulation of diet and dietary rhythm on inflammatory response and mechanisms of enhancing immune function.
• Review or systematic reviews and meta-analyses on this topic.
• Study on the interaction between bioactive substances and viral immune regulation.
Since little is known about the effects of diets, nutrients, and bioactive substances on the occurrence and development of cytokine storms, this research topic aims to disclose novel bioactive ingredients, gut microbiota shaped by diets, and nutrients that can regulate the occurrence and severity of cytokine storm. Furthermore, it is expected to use interdisciplinary methods to study the mechanisms of these activities.
We welcome narrative and systematic reviews (including meta-analyses) and original research studies (animal model, cell model, pre-clinical, translational, and clinical research). Related themes include the following topics but not limited to:
• Research on effects of dietary patterns on inflammatory response and the homeostasis of the immune system.
• Study on anti-inflammatory and immunomodulatory mechanisms of bioactive substances in food.
• Foods, nutrients, bioactive substances, and dietary patterns affect the inflammatory response through intestinal microbiota and their metabolites.
• Study on the regulation of diet and dietary rhythm on inflammatory response and mechanisms of enhancing immune function.
• Review or systematic reviews and meta-analyses on this topic.
• Study on the interaction between bioactive substances and viral immune regulation.
Keywords: Diet, Intestinal microbiota, Metabolites, Bioactive ingredients, Cytokine storm, Proinflammatory cytokines, Anti-inflammatory cytokine, Immune disorders, Systemic inflammation, Viral infection
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
